ArticleStem cell research & therapy2025
Exosomes derived from adipose-derived stem cells alleviate acute radiation-induced dermatitis through up-regulating hyaluronic acid synthase 1 expression.
Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Exosome and biotherapeutic strategies for dermatological and oncological skin complications.Annals of medicine · 2026Review
- Radiotherapy-Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments.MedComm · 2026Review
- ADSC-Exo-bFGF promotes skin wound healing and correlates with the PI3K/AKT signaling pathway activation.Journal of molecular histology · 2026Article
- DNA hydrogel-delivered hypoxic exosomes alleviate radiation-induced skin injury by stabilizing AKT.Journal of nanobiotechnology · 2026Article
- Mesenchymal Stem Cell-Derived Exosomes Mitigate Cutaneous Radiation Injury Through Coordinated Modulation of DNA Repair, Stress, and Inflammatory Gene Programs.Biomedicines · 2026Article
- Exosomes in inflammatory tissue injury: key pathogenic factors and promising therapeutic agents.Frontiers in immunology · 2026Review
- Beyond wound closure: translational opportunities and barriers of mesenchymal stem cells and their extracellular vesicles in burn management.Frontiers in cell and developmental biology · 2026Review
- SteamedNutrients · 2025Article
- The Anti-Aging Effects of Adipose-Derived Mesenchymal Stem Cell Exosomes on Skin and Their Potential for Personalized Skincare Applications.Clinical, cosmetic and investigational dermatology · 2025Review
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8 authors.
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Abstract
backgroundAcute radiation-induced dermatitis refers to skin lesions that usually appear within 90 days of the start of radiotherapy. Although various treatments are available, none have proven fully effective. Exosomes produced by adipose-derived stem cells play crucial roles in enhancing cell regeneration, promoting angiogenesis, regulating inflammation and remodeling the extracellular matrix. Hyaluronic acid, a major extracellular matrix component, is synthesized by hyaluronic acid synthase, with hyaluronic acid synthase 1 being particularly critical for skin repair. This study aimed to investigate whether exosomes derived from adipose-derived stem cells can protect against radiation-induced acute skin damage and to elucidate the underlying mechanisms involving hyaluronic acid synthase 1.
methodsThirty-six male adult SD rats were randomly divided into a negative control group, an irradiation group (90 Gy), and a radiation + exosomes group (90 Gy + 100 ug exosomes). Three groups of fibroblasts were assigned: one for control, one for radiation (6 Gy), and one for radiation plus exosomes (6 Gy + 4 ug exosomes). The effect of ADSC-exos transplantation was evaluated using skin damage score, histopathological analysis, electron microscopy, immunohistochemical staining, immunofluorescence staining, and immunoblotting analysis. Furthermore, small interfering RNA-mediated knockdown of hyaluronic acid synthase 1 was performed to explore its regulatory role in the TGF-β/Smad2/3 signaling pathway.
resultsAfter irradiation, the ADSC-exos intervention significantly increased the levels of stromal cell-derived factor-1, matrix metalloproteinases, transforming growth factor, basic fibroblast growth factor, platelet-derived growth factor, vascular endothelial growth factor, interleukin 10, interleukin 12, and reduced the expression of the pro-inflammatory factor interleukin 6. Notably, exosomes treatment markedly upregulated hyaluronic acid synthase 1 expression, and small interfering RNA-mediated knockdown of hyaluronic acid synthase 1 resulted in reduced phosphorylation of TGF-β/Smad2/3 signaling components, indicating that hyaluronic acid synthase 1 is a critical mediator of this pathway.
conclusionExosomes derived from adipose-derived stem cells alleviate acute radiation-induced dermatitis by enhancing hyaluronic acid synthase 1 expression and activating the TGF-β/Smad2/3 pathway, thereby promoting skin regeneration and repair. These findings suggest that exosomes derived from adipose-derived stem cells may serve as a promising cell-free therapeutic strategy for the prevention and treatment of acute radiation-induced dermatitis.
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