Evidence map›Paper›PMID 40394678›Full record

ArticleBMC research notes2025

Prevalence of high N-terminal prohormone of brain natriuretic peptide levels and associated factors among community-dwelling older adults aged over 75 years (The SONIC study): a cross-sectional study.

Saya Terada, Kayo Godai, Mai Kabayama, Michiko Kido, Yuya Akagi, Hiroshi Akasaka, Yoichi Takami, Takeshi Nakagawa, Saori Yasumoto, Yasuyuki Gondo and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Saya TeradaDepartment of Health Sciences, University of Osaka Graduate School of Medicine, 1-7, Yamadaoka, Osaka, Suita, 565-0871, Osaka, Japan.
Kayo GodaiDepartment of Health Sciences, University of Osaka Graduate School of Medicine, 1-7, Yamadaoka, Osaka, Suita, 565-0871, Osaka, Japan.
Mai KabayamaDepartment of Health Sciences, University of Osaka Graduate School of Medicine, 1-7, Yamadaoka, Osaka, Suita, 565-0871, Osaka, Japan.
Michiko KidoDepartment of Health Sciences, University of Osaka Graduate School of Medicine, 1-7, Yamadaoka, Osaka, Suita, 565-0871, Osaka, Japan.
Yuya AkagiDepartment of Health Sciences, University of Osaka Graduate School of Medicine, 1-7, Yamadaoka, Osaka, Suita, 565-0871, Osaka, Japan.
Hiroshi AkasakaDepartment of Geriatric and General Medicine, University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Osaka, Suita, 565-0871, Osaka, Japan.
Yoichi TakamiDepartment of Geriatric and General Medicine, University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Osaka, Suita, 565-0871, Osaka, Japan.
Takeshi NakagawaDepartment of Clinical Thanatology and Geriatric Behavioral Sciences, Graduate School of Human Sciences, University of Osaka, 1-2 Yamadaoka, Suita, 565-0871, Osaka, Japan.
Saori YasumotoOffice of International Exchange, University of Osaka Graduate School of Human Sciences, 1-2 Yamadaoka, Suita, 565-0871, Osaka, Japan.
Yasuyuki GondoDepartment of Clinical Thanatology and Geriatric Behavioral Sciences, Graduate School of Human Sciences, University of Osaka, 1-2 Yamadaoka, Suita, 565-0871, Osaka, Japan.
Kazunori IkebeFaculty of Dentistry, University of Osaka Graduate School of Dentistry, 1-8 Yamadaoka, Osaka, Suita, 565-0871, Japan.
Yasumichi AraiCenter for Supercentenarian Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.
Yukie MasuiResearch Team for Human Care, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2, Sakae-cho, Itabashi, Tokyo, 173-0015, Japan.
Takumi HirataResearch Team for Human Care, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2, Sakae-cho, Itabashi, Tokyo, 173-0015, Japan.
Koichi YamamotoDepartment of Geriatric and General Medicine, University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Osaka, Suita, 565-0871, Osaka, Japan.
Kei KamideDepartment of Health Sciences, University of Osaka Graduate School of Medicine, 1-7, Yamadaoka, Osaka, Suita, 565-0871, Osaka, Japan. kamide@sahs.med.osaka-u.ac.jp.

Funding

Japan Agency for Medical Research and Development 24dk0110049h0002Japan Society for the Promotion of Science 20H03576Japan Society for the Promotion of Science 22H00089Japan Society for the Promotion of Science 23K24672JST SPRING JPMJSP2138Ministry of Health, Labour and Welfare 23AA2006Ministry of Health, Labour and Welfare K24FA1005Nippon Foundation JM00000160Osaka University's International Joint Research Promotion Program Support Type A J219713005
6 · The paper itself

Abstract

objectivesConsidering the heart failure (HF) pandemic, numerous older adults in the community may exhibit potential cardiac overload or asymptomatic HF without apparent HF diagnosis. This study aimed to examine the distribution of serum N-terminal prohormone of brain natriuretic peptide (NT-proBNP) levels in community-dwelling old age adults aged ≥ 75 years, and to investigate the associated factors for each NT-proBNP classification.

resultsA cross-sectional analysis revealed that 52.0% of 611 participants had NT-proBNP ≥ 125 pg/mL. Multinomial logistic regression analysis showed that female sex, older age (80s and 90s), and uncontrolled high blood pressure were significantly associated with 125 ≤ NT-proBNP < 300 pg/mL, while older age (80s and 90s), coronary artery disease, atrial fibrillation, and renal dysfunction were significantly associated with NT-proBNP ≥ 300 pg/mL. Independent association between higher salt intake and NT-proBNP ≥ 300 pg/mL was also observed. Appropriate management of common HF risk factors, such as uncontrolled high blood pressure and high salt intake, is crucial to prevent the progression of overt HF.

Indexed as

Heart FailureIndependent LivingNatriuretic Peptide, BrainPeptide FragmentsAgedAged, 80 and overAtrial FibrillationBiomarkersCoronary Artery DiseaseCross-Sectional StudiesFemaleHumansHypertensionMalePrevalenceRisk FactorsBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Aging populationAsymptomatic heart failureCardiac overloadCommunityHeart failureNT-proBNPOlder adultsRisk factorsSalt intakeScreening

Identifiers

PMID40394678
PMCPMC12090677

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.