Evidence map›Paper›PMID 40394650›Full record

ArticleJournal of nanobiotechnology2025

Multi-enzymatic biomimetic cerium-based MOFs mediated precision chemodynamic synergistic antibacteria and tissue repair for MRSA-infected wounds.

Shiqi Chen, Yifan Li, Qiang Ma, Jiayi Liang, Zhiyue Feng, Sihan Wang, Shuai Zhang, Ke Han, Boyan Sun, Hongping Wang and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Shiqi Chen *Department of Veterinary Pharmacology and Toxicology, National Key Laboratory of Veterinary Public Health Security, China Agricultural University, Beijing, 100193, China.
Yifan Li *NMPA Key Laboratory for Quality Control and Evaluation of Vaccines and Biological Products, SiChuan Institute of Musk Deer Breeding, SiChuan Institute for Drug Control (Sichuan Testing Center of Medical Devices), Chengdu, 611731, China.
Qiang MaDepartment of Veterinary Pharmacology and Toxicology, National Key Laboratory of Veterinary Public Health Security, China Agricultural University, Beijing, 100193, China.
Jiayi LiangDepartment of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.
Zhiyue FengDepartment of Veterinary Pharmacology and Toxicology, National Key Laboratory of Veterinary Public Health Security, China Agricultural University, Beijing, 100193, China.
Sihan WangDepartment of Veterinary Pharmacology and Toxicology, National Key Laboratory of Veterinary Public Health Security, China Agricultural University, Beijing, 100193, China.
Shuai ZhangDepartment of Veterinary Pharmacology and Toxicology, National Key Laboratory of Veterinary Public Health Security, China Agricultural University, Beijing, 100193, China.
Ke HanDepartment of Veterinary Pharmacology and Toxicology, National Key Laboratory of Veterinary Public Health Security, China Agricultural University, Beijing, 100193, China.
Boyan SunDepartment of Veterinary Pharmacology and Toxicology, National Key Laboratory of Veterinary Public Health Security, China Agricultural University, Beijing, 100193, China.
Hongping WangNMPA Key Laboratory for Quality Control and Evaluation of Vaccines and Biological Products, SiChuan Institute of Musk Deer Breeding, SiChuan Institute for Drug Control (Sichuan Testing Center of Medical Devices), Chengdu, 611731, China. wanghp@scidc.org.cn.
Haiyang JiangDepartment of Veterinary Pharmacology and Toxicology, National Key Laboratory of Veterinary Public Health Security, China Agricultural University, Beijing, 100193, China. haiyang@cau.edu.cn.

Funding

National Natural Science Foundation of China 32373096
6 · The paper itself

Abstract

Antibiotic-resistant pathogens represent a significant global public health challenge, particularly in refractory infections associated with biofilms. Urgent development of innovative, safe, and therapeutically adaptive strategies to combat these resistant biofilms is essential. We present a novel biomimetic antibacterial system inspired by the multifunctional enzymatic properties of cerium-based metal-organic frameworks. This system utilizes the inherent oxidase and peroxidase activities of a nanozyme to generate reactive oxygen species (ROS) for bacterial eradication, while its phosphate-ester hydrolase activity disrupts bacterial genetic material and energy metabolism. By the reversible covalent binding between boronic acid groups and cis-diol groups on bacterial surfaces, combined with abundant cerium catalytic sites from the porous structure and the potent antibacterial effects of sanguinarine, we enhance targeted antibacterial activity. This system effectively penetrates extracellular polymeric substances (EPS) and demonstrates precise regulation of ROS, allowing for localized delivery of ROS and sanguinarine for biofilm eradication. Transcriptomic analyses indicate that this approach disrupts the cellular environment, impairs energy metabolism, inhibits bacterial attachment to EPS, and promotes biofilm dispersion by modulating drug resistance-related genes. In vivo experiments confirm that this nanocatalyst composite effectively treats biofilm-induced wounds with efficacy comparable to vancomycin, presenting a promising solution for managing chronic infections caused by antibiotic-resistant biofilms.

Indexed as

Anti-Bacterial AgentsBiomimetic MaterialsCeriumMetal-Organic FrameworksMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsWound HealingWound InfectionAnimalsBenzophenanthridinesBiofilmsHumansMiceReactive Oxygen SpeciesAnti-Bacterial AgentsBenzophenanthridinesCeriumMetal-Organic FrameworksReactive Oxygen SpeciesAntibacteriaInfected wound healingMRSANanozymesTargeted delivery systems

Identifiers

PMID40394650
PMCPMC12090472

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.