Evidence map›Paper›PMID 40394640›Full record

ArticleHuman genomics2025

Identification of loci associated with women's reproductive traits and exploration of a shared genetic basis with obesity.

Seong-Ah Kwon, Yoon Shin Cho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Seong-Ah KwonDepartment of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon State, Republic of Korea.
Yoon Shin ChoDepartment of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon State, Republic of Korea. yooncho33@hallym.ac.kr.

Funding

National Research Foundation of Korea RS-2023-00245960
6 · The paper itself

Abstract

backgroundThe timing of menarche and menopause significantly affects women's health, with influences on cancer, cardiovascular disease, obesity, type 2 diabetes, and psychosocial problems. In addition, observational studies have reported that ages at menarche (AAM) and natural menopause (ANM) are correlated with obesity. To understand the genetic bases of these reproductive traits, we conducted a genome-wide association study (GWAS) of AAM and ANM in the Korean population. We also investigated the genetic correlation and causal relationship to explore the shared genetic architecture between reproductive traits and obesity in women.

resultsOur GWA analyses of 45,608 and 21,599 adult women identified two and six genome-wide significant associations (P-value < 5 × 10

conclusionsOverall, our study provides insights into the genetic architecture of women's reproductive traits and the shared genetic basis between AAM and obesity. Our MR analyses suggest that the genetic correlation between AAM and obesity traits results from the direct effects of genetic variants on both traits rather than a causal relationship between them.

Indexed as

Genetic Predisposition to DiseaseMenarcheMenopauseObesityReproductionAdultBody Mass IndexFemaleGenome-Wide Association StudyHumansLinkage DisequilibriumMiddle AgedPolymorphism, Single NucleotideRepublic of KoreaAge at menarcheAge at menopauseGenetic correlationGenome-wide association studyMendelian randomization

Identifiers

PMID40394640
PMCPMC12093848

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.