Evidence map›Paper›PMID 40394563›Full record

ArticleJournal of nanobiotechnology2025

A self-assembled multicomponent RNA nano-biopesticide for increasing the susceptibility of destructive bean flower thrips to insecticides via dsNrf2.

Jiajia Zhao, Zeng Wang, Jiaming Yin, Ying Wei, Mingshan Li, Zhongzheng Ma, Meizhen Yin, Min Dong, Jie Shen, Shuo Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiajia ZhaoSanya Institute of China Agricultural University, Sanya, 572025, PR China.
Zeng WangState Key Laboratory of Agricultural and Forestry Biosecurity, Department of Plant Biosecurity, College of Plant Protection, China Agricultural University, Beijing, 100193, China.
Jiaming YinSanya Institute of China Agricultural University, Sanya, 572025, PR China.
Ying WeiState Key Laboratory of Agricultural and Forestry Biosecurity, Department of Plant Biosecurity, College of Plant Protection, China Agricultural University, Beijing, 100193, China.
Mingshan LiState Key Laboratory of Agricultural and Forestry Biosecurity, Department of Plant Biosecurity, College of Plant Protection, China Agricultural University, Beijing, 100193, China.
Zhongzheng MaInstitute of Plant Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, PR China.
Meizhen YinState Key Laboratory of Chemical Resource Engineering, Beijing Lab of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, PR China.
Min DongSanya Institute of China Agricultural University, Sanya, 572025, PR China.
Jie ShenSanya Institute of China Agricultural University, Sanya, 572025, PR China.
Shuo YanSanya Institute of China Agricultural University, Sanya, 572025, PR China. yanshuo2011@foxmail.com.

Funding

National Natural Science Foundation of China 32372631Pinduoduo-China Agricultural University Research Fund PC2023B02018Postdoctoral Fellowship Program (Grad C) of China Postdoctoral Science Foundation GZC20233041Sanya Yazhou Bay Science and Technology City SCKI-JYRC-2022-26
6 · The paper itself

Abstract

High resistance of bean flower thrips (BFT, Megalurothrips usitatus) has led to the unscientific application of insecticides to cause famous "toxic cowpea" incidents in China. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays an important role in inducing antioxidant responses and drug detoxification. Therefore, the detoxification genes may be suppressed to control insecticide resistance via Nrf2. Herein, we demonstrated that the expression of most detoxification genes and enzyme activity were remarkably suppressed via nrf2 RNAi. Subsequently, a novel hydrophilic-lipophilic diblock polymer (HLDP) was developed to co-assemble with dsNrf2 and sulfoxaflor (SUL) into nanoscale SUL/HLDP/dsNrf2 complex (221.52 nm). Excitingly, the SUL/HLDP/dsNrf2 complex exhibited excellent leaf adhesion performance, with the smaller contact angle, reduced surface tension, amplified contact area, improved retention, and enhanced plant uptake. Meanwhile, theSUL/HLDP/dsNrf2 displayed high delivery efficiency in vitro and in vivo, and its insecticidal activity against BFTs was significantly higher than SUL. Furthermore, the required doses of SUL/HLDP/dsNrf2 to achieve similar insecticidal activity were 50.14% and 58.42% of SUL via immersion and oral feeding, respectively. Overall, this study elucidated the regulatory role of nrf2 in the detoxification and metabolism of BFTs and developed a self-assembled multicomponent RNA nano-biopesticide to increase the susceptibility of BFTs to insecticides.

Indexed as

InsecticidesNF-E2-Related Factor 2RNAThysanopteraAnimalsInsecticide ResistanceRNA InterferenceInsecticidesNF-E2-Related Factor 2RNACo-delivery systemDrug adjuvantGene nanocarrierIncreased insecticide susceptibilityMulticomponent RNA nano-biopesticide

Identifiers

PMID40394563
PMCPMC12090644

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.