ArticleBMC cancer2025
EGFR exon 20 insertions mutation in lung adenocarcinoma and its response by high-dose of Furmonertinib: a real-world study.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Real-world prevalence of actionable genomic alterations detected by next-generation sequencing in non-small cell lung cancer: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Flumonertinib after prior third-generation EGFR-tyrosine kinase inhibitor (TKI) therapy in patients with epidermal growth factor receptor-mutated non-small cell lung cancer after resistance to third-generation tyrosine kinase inhibitor treatment: a real-world study.Journal of thoracic disease · 2026Article
- Exceptional response to furmonertinib in lung adenocarcinoma harboring HER2 exon 20 insertion mutation: a case report.Frontiers in oncology · 2026Article
- Sunvozertinib: a Promising Oral EGFR Inhibitor Approved for NSCLC with EGFR Ex20ins Mutations.Investigational new drugs · 2025Review
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Authors and funding
11 authors.
Funding
Abstract
backgroundLUAD patients with EGFR exon 20 insertions (ex20ins) have a poorer prognosis than those with EGFR 19del or L858R mutations. The FAVOUR study showed high-dose furmonertinib's efficacy in ex20ins patients. However, more real-world data are needed to validate these findings.
methodsWe summarized LUAD patients who underwent NGS testing at Henan Cancer Hospital from January 1, 2020, to December 31, 2022. We then reviewed cases of patients with EGFR exon 20 insertion (ex20ins) mutations who received high-dose furmonertinib (240 mg/day) and had follow-up data. We assessed the objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), time to treatment failure (TTF), overall survival (OS), and treatment-related adverse events (TRAEs).
resultsA total of 3,571 patients underwent NGS testing, with 1,632 (45.70%) identified as having EGFR mutations, including 87 (2.44%) with exon 20 insertions (ex20ins). Follow-up data were complete for 21 ex20ins patients treated with 240 mg/d of furmonertinib. Thirteen had prior treatments, including targeted therapy, and four had received EGFR-TKI. By March 1, 2024, 18 patients progressed, and 13 died. The ORR was 52.40% (11/21), DCR was 100%, median PFS was 6.15 months, TTF was 10.78 months, and OS was 21.67 months. Among the 18 progressing patients, 11 had neurological progression, six had thoracic progression, and two had liver progression. Diarrhea was the most common adverse event, and no patients discontinued treatment due to AEs.
conclusionsAmong LUAD patients, 2.44% harbored EGFR exon 20 insertions (ex20ins), and furmonertinib at 240 mg/d demonstrated efficacy and was well-tolerated in this real-world study of LUAD patients with EGFR ex20ins mutations.
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