Evidence map›Paper›PMID 40394522›Full record

ArticleBMC gastroenterology2025

Clinical efficacy of TACE using coil or gelatin sponge combined with targeted therapy in the treatment of giant hepatocellular carcinoma with arterioportal fistulas.

Zhijuan Wu, Min Zhang, Ruirui Tian, Jibing Liu, Xu Chang, Shangkun Ning, Yingli Yu, Lin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhijuan Wu *Department of Gerontology, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Min Zhang *Department of Breast and Thyroid Surgery, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.
Ruirui TianDepartment of Oncology, Dongying District People's Hospital, Dong Ying City, Shandong Province, China.
Jibing LiuDepartment of Interventional Therapy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Xu ChangDepartment of Interventional Therapy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Shangkun NingDepartment of Interventional Therapy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Yingli YuDepartment of Interventional Therapy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Lin ZhangDepartment of Interventional Therapy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China. zhanglin20121212@yeah.net.

Funding

Natural Science Foundation of Shandong Province ZR2020QH177Shandong Provincial Natural Science Foundation for Youth ZR2023QH448Shandong Traditional Chinese Medicine Science and Technology Project Q-2022110
6 · The paper itself

Abstract

backgroundThe present study aimed to evaluate the effectiveness of spring coils or gelatin sponges for the embolization of giant hepatocellular carcinoma (HCC) with a hepatic arterioportal shunt (APS) in targeted therapy.

methodsA total of 81 patients with a large HCC complicated with APS were divided into two groups on the basis of the use of block-APS embolic agents: the coil group and the gelatin sponge group. Both groups received lipiodol transarterial chemoembolization (TACE) after APS was correspondingly blocked with a coil or gelatin sponge. Sorafenib or lenvatinib was administered 3-5 days before TACE.

resultsBoth groups showed improvement in the incidence of fistula one month after the first TACE session and the last TACE session compared with before treatment. In addition, the improvement in the incidence of fistulas in the coil group was greater than that in the gelatin sponge group [p = 0.003], whereas the compensation of extrahepatic blood vessels was more severe in the coil group. There was no significant difference in median overall survival (OS) (11.13 months, 95% CI 7.67-14.59 months vs. 15.13 months, 95% CI 10.18-20.09 months, p = 0.303) or progression-free survival (PFS) (5.37 months, 95% CI 5.04-5.70 months vs. 5.7 months, 95% CI 0.66-10.74 months, p = 0.376) between the two groups. However, both groups showed early progression of intrahepatic lesions.

conclusionsSpring coil or gelatin sponge embolization combined with APS was used for giant HCC patients, which significantly improved the incidence of fistulas.

Indexed as

Arteriovenous FistulaCarcinoma, HepatocellularChemoembolization, TherapeuticGelatin Sponge, AbsorbableLiver NeoplasmsPortal VeinAgedAntineoplastic AgentsCombined Modality TherapyEthiodized OilFemaleHepatic ArteryHumansMaleMiddle AgedPhenylurea CompoundsAntineoplastic AgentsEthiodized OillenvatinibPhenylurea CompoundsQuinolinesSorafenibArterioportal shuntCoilGelatin spongeHepatocellular carcinomaTransarterial chemoembolization

Identifiers

PMID40394522
PMCPMC12090417

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.