Observational studyBMC cardiovascular disorders2025
Serum uric acid and coronary artery disease risk: a 10-year prospective cohort study in healthy adults.
Observational study in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Correlation between hyperuricemia and coronary artery calcification.The Journal of international medical research · 2026Review
- Association between serum uric acid and high-risk plaques assessed by coronary CT angiography.Open heart · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of serum uric acid (SUA) as an independent risk factor for coronary artery disease (CAD) remains controversial, particularly in understudied Middle Eastern populations with distinct metabolic and dietary profiles.
objectiveTo investigate the association between SUA levels and 10-year CAD incidence in a healthy Iranian cohort, adjusting for cardiometabolic confounders and exploring sex-specific relationships.
methodsA 10-year prospective cohort study was conducted using data from the Yazd Healthy Heart Project. Cluster-random sampling recruited adults aged 20-74 years free of baseline cardiovascular disease. Participants with existing coronary artery disease, insufficient data, or loss to follow-up were excluded. Serum uric acid levels were stratified into quartiles, and Cox proportional hazards models adjusted for demographic, lifestyle, and metabolic variables were analyzed using SPSS (version 27.0).
resultsOver 15,420 person-years, 225 incident CAD cases occurred (14.5% cumulative incidence). In crude analysis, the highest SUA quartile (Q4: > 5.2 mg/dL) was associated with increased CAD risk (HR = 1.66, 95% CI: 1.14-2.43). However, this association attenuated after adjustment for confounders (fully adjusted HR = 1.03, 95% CI: 0.62-1.69). Sex-stratified analysis revealed a transient association in women (crude HR = 2.13, 95% CI: 1.14-3.96), which dissipated post-adjustment, while no significant association was observed in men.
conclusionElevated SUA levels were not independently associated with CAD risk in this healthy Middle Eastern cohort. Initial associations were attributable to confounding by metabolic factors such as obesity, dyslipidemia, and hypertension. These findings underscore the importance of contextualizing SUA's role within population-specific risk profiles and highlight the need for nuanced risk stratification strategies.
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