Observational studyBMC gastroenterology2025
Better diagnostic accuracy for GERD observed with the new MNBI cutoff: an observational study in Vietnam.
Observational study in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Asia Is Not the West: Mean Nocturnal Baseline Impedance Must Be Interpreted in a Device- and Region-specific Context.Journal of neurogastroenterology and motility · 2026Article
- Vietnam Association of Gastroenterology (VNAGE) guideline on the management of gastroesophageal reflux disease.Frontiers in medicine · 2026Review
- The Prevalence of Esophageal Hypomotility and Its Relationship With Dysmotility Score in Vietnamese Patients Having Reflux Symptoms.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Comprehensive Assessment of Reflux Burden and Mucosal Integrity in Children: Insights from MNBI and Impedance-pH Monitoring.Children (Basel, Switzerland) · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMean nocturnal baseline impedance (MNBI) is a novel metric for multichannel ambulatory impedance and pH (MI-pH) monitoring used to diagnose gastroesophageal reflux disease (GERD); however, its thresholds vary among different geographic areas and measuring systems. This study analyzed MI-pH data from Vietnamese patients to assess the diagnostic utility of novel MNBI thresholds in identifying GERD.
methodsThis retrospective study included 133 patients suspected of having GERD who underwent upper gastrointestinal endoscopy, esophageal high-resolution manometry (HRM) and 24-hour MI-pH monitoring (Laborie). The subjects were divided into 3 groups based on the acid exposure time (AET) index (abnormal, inconclusive and normal AET). The mean MNBI and the prevalence of abnormal MNBI values were compared within groups, and the diagnostic accuracy of this index for diagnosing GERD was evaluated via receiver operating characteristic (ROC) curves and their area under the curve (AUC).
resultsMNBI was significantly lower in patients with abnormal AET. The prevalence of MNBI < 2292 Ohms and MNBI < 1500 Ohms were greater in patients with abnormal AET (91.2% and 79.4%, respectively). The percentage of MNBI > 2500 Ohms was 44.4% in patients with normal AET but only 2.9% in patients with abnormal AET. MNBI had the highest AUC in discriminating abnormal AET (0.90, p < 0.001) in comparison with other metrics on MI-pH monitoring. The new cutoff value of 1500 Ohms had lower sensitivity but higher specificity than the previous threshold of 2292 Ohms. A multivariable regression analysis revealed that an MNBI < 1500 Ohms and total number of reflux events > 80/day were significantly associated with abnormal AET (> 6%).
conclusionsAmong Vietnamese patients with suspected GERD, the new MNBI cutoff of > 1500 Ohms had high sensitivity and specificity in diagnosing GERD, while the cutoff of 2500 Ohms could rule out this disease.
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