Evidence map›Paper›PMID 40394447›Full record

ArticleArchives of sexual behavior2025

Gender Dysphoria and Detransitioning in Adults: An Analysis of Nine Patients from a Gender Identity Clinic from Finland.

Kaisa Kettula, Niina Puustinen, Lotta Tynkkynen, Liisa Lempinen, Katinka Tuisku

Abstract read
In one paragraph

Article in Archives of sexual behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kaisa KettulaGender Identity Clinic, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland. kaisa.kettula@hus.fi.ORCID 0000-0002-6998-5675
Niina PuustinenOutpatient Clinic for Assessment of Ability to Work, University of Helsinki, and Helsinki University Hospital, PL 250, HUS, 00029, Helsinki, Finland.
Lotta TynkkynenGender Identity Clinic, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
Liisa LempinenOutpatient Clinic for Assessment of Ability to Work, University of Helsinki, and Helsinki University Hospital, PL 250, HUS, 00029, Helsinki, Finland.
Katinka TuiskuGender Identity Clinic, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.

Funding

Helsingin ja Uudenmaan Sairaanhoitopiiri TYH2021128
6 · The paper itself

Abstract

The aim of this study was to analyze the pathways of detransitioning, which is a rare, but serious complication of gender-affirming treatments (GATs). The patient group consisted of all patients who were referred to the Helsinki University Hospital's Gender Identity Clinic (GIC) wanting medical treatment for detransition from 2018 to 2019. A new assessment was made systematically and retrospective data were collected. The sample consisted of nine patients originally diagnosed with gender identity disorder (F64.0). Seven of them were assigned female at birth and two were assigned male at birth. All seven females at birth had "major" regret and both males at birth had "minor" regret. All patients except one male assigned at birth wanted their previous GAT to be reversed. The mean regret time (i.e., time from the first diagnosis of F64.0 to the beginning of the new evaluation period) was seven years. The detransitioners had a high number of psychiatric diagnoses. Childhood trauma, sexual abuse or rape, eating disorder symptoms, borderline personality, and psychotic symptoms were common among detransitioners. Retrospectively, the patients reported that the need for transitioning in the first place was not the transgender identity or gender dysphoria, but reasons related to the maturation process and unresolved psychological stressors. An assessment made by the psychologist at the GIC revealed childhood trauma and severe challenges in parenting and attachment. It is important to acknowledge, support, and evaluate those regretting treatments and/or detransition, and to learn from them.

Indexed as

Gender-Affirming ProceduresGender DysphoriaGender IdentityTransgender PersonsAdultFemaleFinlandHumansMaleMiddle AgedRetrospective StudiesYoung AdultDetransitionGender dysphoriaGender identity disorderICDRegretTransgender

Identifiers

PMID40394447
PMCPMC12162753

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.