Evidence map›Paper›PMID 40394415›Full record

ArticleOncogene2025

A multi-faceted discovery strategy identifies functional antibodies binding to cysteine-rich domain 1 of hDKK1 for cancer immunotherapy via Wnt non-canonical pathway.

Linya Wang, Sean M Peterson, Marisa Yang, Ana G Lujan Hernandez, Tom Z Yuan, Zhen Han, Vishwas Prabhu, Kara Y Chan, Cameron F Hu, Mouna Villalta and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Linya WangTwist Bioscience, South San Francisco, CA, USA. yoyuay@gmail.com.ORCID http://orcid.org/0009-0008-6816-215X
Sean M PetersonTwist Bioscience, South San Francisco, CA, USA.
Marisa YangTwist Bioscience, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9898-2094
Ana G Lujan HernandezTwist Bioscience, South San Francisco, CA, USA.
Tom Z YuanTwist Bioscience, South San Francisco, CA, USA.
Zhen HanTwist Bioscience, South San Francisco, CA, USA.
Vishwas PrabhuTwist Bioscience, South San Francisco, CA, USA.
Kara Y ChanTwist Bioscience, South San Francisco, CA, USA.
Cameron F HuTwist Bioscience, South San Francisco, CA, USA.
Mouna VillaltaTwist Bioscience, South San Francisco, CA, USA.
Tammy HtoyTwist Bioscience, South San Francisco, CA, USA.
Paul VanDykeTwist Bioscience, South San Francisco, CA, USA.
Carson HollidayTwist Bioscience, South San Francisco, CA, USA.
Hector FrancoTwist Bioscience, South San Francisco, CA, USA.
Hansika WadhwaTwist Bioscience, South San Francisco, CA, USA.
Hoa GiangTwist Bioscience, South San Francisco, CA, USA.
Ryan StaffordTwist Bioscience, South San Francisco, CA, USA.
Fumiko AxelrodTwist Bioscience, South San Francisco, CA, USA.
Aaron SatoTwist Bioscience, South San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wnt signaling is important in embryonic development and tumorigenesis. These biological effects can be exerted by the activation of the β-catenin-dependent canonical pathway or the β-catenin-independent non-canonical pathway. DKK1 is a potent inhibitor of Wnt signaling by competing with Wnt binding to LRP5/6 co-receptors. DKK1 is tumorigenic in multiple cancer types and immunosuppressive in NK cells. Emerging evidence indicates that DKK1 is involved in T cell differentiation and induces cancer evasion of immune surveillance by accumulating MDSCs. Consequently, DKK1 has become a promising target for cancer immunotherapy, and the mechanisms by which DKK1 affects cancer and immune cells have received considerable attention. Using Twist's precision DNA writing technologies, we created phage display libraries with a diversity greater than 1 × 10

Indexed as

ImmunotherapyIntercellular Signaling Peptides and ProteinsNeoplasmsWnt Signaling PathwayAnimalsCell Line, TumorHumansLow Density Lipoprotein Receptor-Related Protein-6MiceDKK1 protein, humanIntercellular Signaling Peptides and ProteinsLow Density Lipoprotein Receptor-Related Protein-6

Identifiers

PMID40394415
PMCPMC12301234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.