ArticleInternational ophthalmology2025
Development of a scoring model integrating inflammatory markers for predicting ROP in preterm neonates.
Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Association of vitamin D status with novel hemogram-derived inflammatory indices in preterm infants.BMC pediatrics · 2026Article
- Association of early hyperglycemia with morbidity and mortality in very low birth weight infants.BMC pediatrics · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeROP is a leading cause of blindness in preterm infants worldwide. ROP diagnosis is made through a detailed eye examination and supportive methods are required, especially in limited centers. ROP diagnosis primarily relies on frequent ophthalmological examinations; however, complementary diagnostic tools may significantly aid clinicians, particularly in centers with limited resources. This study introduces an innovative scoring model integrating systemic inflammatory markers for its early prediction of ROP.
methodsA retrospective case-control study involving 120 preterm infants (≤ 32 weeks, ≤ 1500 g) was conducted. Hemogram-based inflammatory indices, including the Systemic Inflammatory Response Index (SIRI), Platelet-to- Lymphocyte Ratio (PLR), and Pan-Immun Inflammatory Value (PIV), were calculated from blood samples obtained within the first 24 h of life and before ROP diagnosis. Logistic regression and ROC analyses informed the scoring model.
resultsInfants with ROP showed lower gestational ages and birth weights (p < 0.001, p = 0.02). SIRI-2 displayed the highest diagnostic accuracy (AUC = 0.704). A combined model using SIRI-2, PLR-2, and PIV-2 achieved superior performance (AUC = 0.802). Logistic regression identified SIRI-2 and PLR-2 as independent predictors, enhancing risk stratification.
conclusionThis scoring model not only enhances early risk stratification but also holds potential for widespread implementation in neonatal intensive care units, particularly in resource-limited settings. Future multicenter trials will further establish its role in optimizing neonatal outcomes globally.
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