Evidence map›Paper›PMID 40394278›Full record

ArticleScientific reports2025

Miniaturized side-firing intracardiac photoacoustic imaging catheter for monitoring radiofrequency ablation.

Shang Gao, Yang Wang, Ryo Murakami, Hiroshi Ashikaga, Young-Ho Kim, Mohammad Mehrmohammadi, Henry R Halperin, Haichong K Zhang

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shang GaoDepartment of Robotics Engineering, Worcester Polytechnic Institute, 100 Institute Rd, Worcester, MA, 01609, USA. sgao@wpi.edu.
Yang WangDepartment of Robotics Engineering, Worcester Polytechnic Institute, 100 Institute Rd, Worcester, MA, 01609, USA.
Ryo MurakamiDepartment of Robotics Engineering, Worcester Polytechnic Institute, 100 Institute Rd, Worcester, MA, 01609, USA.
Hiroshi AshikagaJohn A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, Honolulu, HI, 96813, USA.
Young-Ho KimDigital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ, 08540, USA.
Mohammad MehrmohammadiDepartment of Imaging Sciences, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY, 14642, USA.
Henry R HalperinDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD, 21205, USA.
Haichong K ZhangDepartment of Robotics Engineering, Worcester Polytechnic Institute, 100 Institute Rd, Worcester, MA, 01609, USA. hzhang10@wpi.edu.

Funding

PSMA-based Cancer Imaging AgentsR01CA134675 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI POMPER, MARTIN G · 2009 to 2025
$6.2M
Physician Assistance Technology in Image-guided Robotic Intervention of ProstateR01EB030539 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI HATA, NOBUHIKO, ZHANG, HAICHONG · 2021 to 2024
$2.7M
Automatic Wide-Field Optical Coherence Tomography for Assessment of Transplant Kidney ViabilityR01DK133717 · NIDDK · UNIVERSITY OF MASSACHUSETTS AMHERST · PI POTTER, STEVEN, TANG, QINGGONG · 2022 to 2025
$2.5M
Intraprocedure Model-Guided ElectrophysiologyR01EB022011 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI HALPERIN, HENRY R · 2018 to 2021
$2.3M
Robotic Lung Ultrasound for Triage of COVID-19 Patients in a Resource-Limited EnvironmentDP5OD028162 · OD · WORCESTER POLYTECHNIC INSTITUTE · PI ZHANG, HAICHONG · 2019 to 2023
$2.3M
NCI NIH HHS R01 CA134675NIBIB NIH HHS R01 EB022011NIBIB NIH HHS R01 EB030539NIDDK NIH HHS R01 DK133717NIH HHS DP5 OD028162NIH HHS R01CA134675NIH HHS R01EB022011Worcester Polytechnic Institute Internal fund: the Transformative Research and Innovation, Accelerating Discovery (TRIAD) grant
6 · The paper itself

Abstract

In this paper, we introduce a miniaturized intracardiac photoacoustic (PA) imaging system based on a phased-array intracardiac echocardiography catheter. This PA imaging system enhances imaging feedback during radiofrequency (RF) ablation for atrial fibrillation (A-fib) by providing ablation-induced lesion mapping. The PA imaging catheter with a 4-mm diameter was designed, featuring flexible tip for bending and navigation through the vessels. The catheter's imaging resolution was evaluated using a phantom study with 0.2-mm-diameter wires. In an ex vivo study, the catheter was used to detect ablation-induced necrosis in porcine cardiac tissue, evaluating its capability to image through blood layer and differentiate necrotic tissue based on spectral characteristics. The catheter achieved an imaging resolution of 647.35 ± 61.60 µm in the phantom study. In the ex vivo study, it successfully identified necrotic lesions on porcine cardiac tissue, distinguishing these from surrounding tissue based on spectral analysis. The catheter system successfully imaged through an 8-mm blood layer, effectively highlighting necrotic regions. The proposed miniaturized PA imaging catheter demonstrated high-resolution imaging capability and effective detection of ablation-induced tissue boundary. Its flexibility and small diameter allow for maneuverability through cardiac vessels, enhancing its utility for intraoperative feedback during RF ablation procedures. This advancement offers a practical tool for improving the precision and effectiveness of RF ablation in A-fib treatment by integrating high-resolution imaging and maneuverability into a PA imaging catheter, potentially facilitating its adoption in clinical practice.

Indexed as

Atrial FibrillationCatheter AblationPhotoacoustic TechniquesRadiofrequency AblationAnimalsCathetersEchocardiographyEquipment DesignMiniaturizationPhantoms, ImagingSwine

Identifiers

PMID40394278
PMCPMC12092788

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.