Evidence map›Paper›PMID 40394254›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Retrospective analysis of different application methods in intratympanic glucocorticoid therapy for treatment of idiopathic SSNHL: A comparative outcome study.

C Schmit, F Keller, T Gottfried, M Santer, A Tröger, M Kloppenburg, J Klarer, A Stenzl, J Schmutzhard, B Hofauer and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

C SchmitUniversitätsklinik Für Hals-, Nasen- und Ohrenheilkunde, Medizinische Universität Innsbruck, Anichstraße 35, A-6020, Innsbruck, Österreich.
F KellerUniv.-Klinik Für Innere Medizin IV (Nephrologie Und Hypertensiologie), Medizinische Universität Innsbruck, Innsbruck, Austria.
T GottfriedUniversitätsklinik Für Hals-, Nasen- und Ohrenheilkunde, Medizinische Universität Innsbruck, Anichstraße 35, A-6020, Innsbruck, Österreich. Timo.Gottfried@i-med.ac.at.ORCID http://orcid.org/0000-0002-1022-6877
M SanterUniversitätsklinik Für Hals-, Nasen- und Ohrenheilkunde, Medizinische Universität Innsbruck, Anichstraße 35, A-6020, Innsbruck, Österreich.
A TrögerUniversitätsklinik Für Hals-, Nasen- und Ohrenheilkunde, Medizinische Universität Innsbruck, Anichstraße 35, A-6020, Innsbruck, Österreich.
M KloppenburgUniversitätsklinik Für Hals-, Nasen- und Ohrenheilkunde, Medizinische Universität Innsbruck, Anichstraße 35, A-6020, Innsbruck, Österreich.
J KlarerUniversitätsklinik Für Hals-, Nasen- und Ohrenheilkunde, Medizinische Universität Innsbruck, Anichstraße 35, A-6020, Innsbruck, Österreich.
A StenzlUniversitätsklinik Für Hals-, Nasen- und Ohrenheilkunde, Medizinische Universität Innsbruck, Anichstraße 35, A-6020, Innsbruck, Österreich.
J SchmutzhardUniversitätsklinik Für Hals-, Nasen- und Ohrenheilkunde, Medizinische Universität Innsbruck, Anichstraße 35, A-6020, Innsbruck, Österreich.
B HofauerUniversitätsklinik Für Hals-, Nasen- und Ohrenheilkunde, Medizinische Universität Innsbruck, Anichstraße 35, A-6020, Innsbruck, Österreich.
D DejacoUniversitätsklinik Für Hals-, Nasen- und Ohrenheilkunde, Medizinische Universität Innsbruck, Anichstraße 35, A-6020, Innsbruck, Österreich.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGlucocorticoids for sudden sensorineural hearing loss (SSNHL) can be administered systemically or via intratympanic injection. This study evaluates the impact of different intratympanic injection techniques on patient outcomes.

methodsA retrospective analysis was conducted on patients diagnosed with idiopathic SSNHL (January 2008-May 2023). Patients were grouped by application technique: (1) transtympanic injection under local anesthesia (TI), (2) CO

resultsThe study included 99 patients: 28 with TI, 34 with VT, and 37 with LP. Groups showed no significant differences in sex, affected side, therapy initiation interval, pretreatment type, preoperative BCPTA4, subjective improvement, or treatment-related pain (all p > 0.1). Hearing thresholds improved significantly in the LP and VT groups with large (d = 0.832, p < 0.001) and medium (d = 0.513, p = 0.01) effect sizes, respectively, but not in the TI group (d = 0.294, p = 0.137). Tympanic membrane closure time differed significantly among groups (p < 0.001).

conclusionsLP and VT significantly improved hearing thresholds in SSNHL patients. LP demonstrated the highest efficacy, consistent results across SSNHL severities, and the fastest tympanic membrane closure, making it the preferred method.

Indexed as

GlucocorticoidsHearing Loss, SensorineuralHearing Loss, SuddenAdultAgedAnesthesia, GeneralAnesthesia, LocalFemaleHumansInjection, IntratympanicMaleMiddle AgedParacentesisRetrospective StudiesTreatment OutcomeTympanic Membrane PerforationGlucocorticoidsCO2-laserHearing outcomesIntratympanic glucocorticoid injectionSudden hearing loss

Identifiers

PMID40394254
PMCPMC12518391

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.