Evidence map›Paper›PMID 40394178›Full record

ArticleScientific reports2025

1-Phenyl-β-carboline-3-carboxamide-1,2,3-triazole-N-phenylacetamide hybrids as new α-glucosidase inhibitors.

Elham Safaie, Mohammad Hosein Sayahi, Navid Dastyafteh, Mohammad Halimi, Milad Noori, Maryam Mohammadi-Khanaposhtani, Afsaneh Zonouzi, Roghieh Mirzazadeh, Azadeh Tajmir-Riahi, Somayeh Mojtabavi and 4 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Elham Safaie *Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Hosein Sayahi *Department of Chemistry, Payame Noor University, Tehran, Iran.
Navid DastyaftehEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad HalimiDepartment of Biology, Babol Branch, Islamic Azad University, Babol, Iran.
Milad NooriEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Maryam Mohammadi-KhanaposhtaniCellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Afsaneh ZonouziSchool of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Roghieh MirzazadehBiochemistry Department, Pasteur Institute of Iran, Tehran, Iran.
Azadeh Tajmir-RiahiSchool of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Somayeh MojtabaviDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Ali FaramarziDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Bagher LarijaniEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mehdi AsadiRazi Drug Research Center, University of Medical Sciences, Tehran, Iran. asadi.meh@iums.ac.ir.
Mohammad MahdaviEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. momahdavi@tums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, 1-phenyl-β-carboline-3-carboxamide-1,2,3-triazole-N-phenylacetamide skeleton as a novel scaffold was designed based on hybridization of moieties that were found in the potent α-glucosidase inhibitors. Fourteen derivatives 14a-n of this scaffold were synthesized by the efficient chemical reactions. In vitro anti-α-glucosidase assay demonstrated that all the new fourteen derivatives with IC

Indexed as

alpha-GlucosidasesCarbolinesGlycoside Hydrolase InhibitorsTriazolesAnimalsHumansKineticsRatsStructure-Activity Relationshipalpha-GlucosidasesCarbolinesGlycoside Hydrolase InhibitorsTriazoles1,2,3-Triazoleα-Glucosidaseβ-Carboline

Identifiers

PMID40394178
PMCPMC12092823

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.