Evidence map›Paper›PMID 40394132›Full record

ArticleScientific reports2025

SLAMF8 and NINJ2 promote neuroinflammation and oxidative stress through TLR4 NF kappa B pathway in Alzheimer's disease.

Shuo Liu, Yuze He, He Chen, Wenwen Zhao, Heman Xu, Tao Bai, Juan Feng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuo LiuThe Fourth People's Hospital of Shenyang, Shenyang, Liaoning, China.
Yuze HeShengjing Hospital of China Medical University, China Medical University, Shenyang, China.
He ChenThe Fourth People's Hospital of Shenyang, Shenyang, Liaoning, China.
Wenwen ZhaoThe Fourth People's Hospital of Shenyang, Shenyang, Liaoning, China.
Heman XuThe Fourth People's Hospital of Shenyang, Shenyang, Liaoning, China.
Tao BaiShengjing Hospital of China Medical University, China Medical University, Shenyang, China.
Juan FengShengjing Hospital of China Medical University, China Medical University, Shenyang, China. 2022140168@cmu.edu.cn.

Funding

the Key Research and Development Program of Liaoning Province 2020JH2/10300047
6 · The paper itself

Abstract

This study aimed to investigate the expression and role of Signaling Lymphocytic Activation Molecule Family Member 8 (SLAMF8) in Alzheimer's disease (AD), particularly its interaction with NINJ2 in the TLR4/NF-κB signaling pathway. SLAMF8 expression levels in AD models were analyzed using the Gene Expression Omnibus (GEO) database. Validation of SLAMF8 expression was conducted through RT-PCR and Western blot in Aβ

Indexed as

Alzheimer DiseaseNeuroinflammatory DiseasesNF-kappa BOxidative StressToll-Like Receptor 4Amyloid beta-PeptidesAnimalsCell Line, TumorDisease Models, AnimalHumansMiceMice, TransgenicSignal TransductionAmyloid beta-PeptidesNF-kappa BTLR4 protein, humanToll-Like Receptor 4Alzheimer’s disease (AD)NeuroinflammationNINJ2Oxidative stressSLAMF8Therapeutic targetsTLR4/NF-κB pathway

Identifiers

PMID40394132
PMCPMC12092773

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.