Substituted benzylamino-2'-deoxyadenosine a modified nucleoside with radiosensitizing properties.

Magdalena Datta, Adrian Szczyrba, Anna Czaja, Magdalena Zdrowowicz, Sebastian Demkowicz, Janusz Rak

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Magdalena DattaLaboratory of Biological Sensitizers, Department of Physical Chemistry, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdańsk, Poland.

Adrian SzczyrbaLaboratory of Biological Sensitizers, Department of Physical Chemistry, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdańsk, Poland.

Anna CzajaLaboratory of Biological Sensitizers, Department of Physical Chemistry, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdańsk, Poland.

Magdalena ZdrowowiczLaboratory of Biological Sensitizers, Department of Physical Chemistry, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdańsk, Poland.

Sebastian DemkowiczDepartment of Organic Chemistry, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza 11/12, 80-233, Gdańsk, Poland.

Janusz RakLaboratory of Biological Sensitizers, Department of Physical Chemistry, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdańsk, Poland. janusz.rak@ug.edu.pl.

Funding

Polish National Science Center Ceus-Unisono, Grant No. UMO-2020/02/Y/ST4/0011Uniwersytet Gdański BMN/539-T080-B985-23

6 · The paper itself

Abstract

To verify whether the recently synthesized nucleoside, 8-(4-Trifluoromethoxy)benzylamino-2'-deoxyadenosine, can sensitize tumorous cells to X-rays, radiolytic and in vitro studies have been conducted. Molecular modeling demonstrated that excess electrons should lead to efficient dissociative electron attachment (DEA) to dA-NHbenzylOCF

Indexed as

DeoxyadenosinesNucleosidesRadiation-Sensitizing AgentsCell CycleCell Line, TumorCell SurvivalHumansMCF-7 CellsX-RaysDeoxyadenosinesNucleosidesRadiation-Sensitizing AgentsCell cycleClonogenic assayDissociative electron attachmentMTT testRadiosensitizing nucleosides

Identifiers

PMID40394130

DOI10.1038/s41598-025-99262-8

PMCPMC12092623

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.