ArticleScientific reports2025
Association of red blood cell count, hemoglobin concentration, and inflammatory indices with cognitive impairment severity in Alzheimer's disease.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A combined neuronal extracellular vesicle-haematology panel for clinical stratification of Alzheimer's disease and dementia.Metabolic brain disease · 2026Article
- Intelectin-1 and systemic inflammation indices as potential biomarkers in alzheimer's disease.Metabolic brain disease · 2026Article
- Evaluate the Risk Factors of Mild Cognitive Impairment (MCI) in Patients with Type 2 Diabetes Mellitus (T2DM): A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- An integrated CSF-serum biomarker model for predicting clinical progression in Alzheimer's disease.Frontiers in aging neuroscience · 2026Article
- Article
- Machine learning-based risk prediction model for cognitive dysfunction in elderly individuals.PloS one · 2025Article
- Hemoglobin-to-red blood cell distribution width ratio in the relationship between occupational aluminum exposure and cognitive function impairment: a mediation analysis.Frontiers in public health · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Some studies have found that patients with Alzheimer's disease (AD) have changes in levels of red blood cell (RBC) and hemoglobin (HB), and some inflammatory indexes are increased. However, the results of relevant studies are not uniform. The aim of this study is to investigate the changes of RBC, HB, and commonly used inflammatory indexes in patients with AD and their correlation with the severity of cognitive impairment. A total of 225 subjects with AD and 2000 healthy controls were included. Dementia severity was evaluated by Mini-Mental State Examination (MMSE). The RBC count and HB concentration of subjects were detected, and inflammatory indexes including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and monocyte/lymphocyte ratio (MLR), systemic immune inflammation index (SII), systemic inflammation response index (SIRI), and pan-immune-inflammation value (PIV) were calculated. RBC count, HB concentration, NLR, PLR, MLR were independent influencing factors for AD. RBC count and HB concentration are significantly associated with the severity of cognitive impairment in AD patients. RBC count has a significant effect on the severity of cognitive impairment without considering the education level, but their effects on the severity of cognitive impairment are no longer significant when the education level is considered. The RBC count and HB concentration of AD patients are decreased, and are correlated with the severity of cognitive impairment. In addition, some inflammatory indexes are associated with the risk of AD.
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