ArticleScientific reports2025
Brain structural differences between fibromyalgia patients and healthy control subjects: a source-based morphometric study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural and Functional Neuroimaging Findings in Fibromyalgia: A Systematic Review.European journal of pain (London, England) · 2026Pooled it
- Efficacy and mechanism of supervised adapted physical activity on quality of life for patients with fibromyalgia: single-center, prospective, randomised clinical and neuroimaging study.Scientific reports · 2026Trial
- Fibromyalgia and Risk of Alzheimer's DiseaseRelated Dementia: A Nationwide Bidirectional Case-Control Study.Geriatrics (Basel, Switzerland) · 2026Article
- A randomised, double-blind, sham-controlled, 2×2 factorial trial of aerobic vs. non-aerobic exercise and motor cortex transcranial direct current stimulation in fibromyalgia: effects on clinical outcomes and descending pain modulation.Lancet regional health. Americas · 2026Article
- Enhanced interhemispheric functional connectivity in patients with functional anorectal pain.Scientific reports · 2025Article
- An Imaging-Based Investigation of the Potential Relationship Between Trigeminal Nerve Microstructure, Paranasal Sinus Volumes, and Headache in Fibromyalgia.Journal of clinical practice and research · 2025Article
- The Casual Associations Between Brain Functional Networks and Fibromyalgia: A Large-Scale Genetic Correlation and Mendelian Randomization Study.Bioengineering (Basel, Switzerland) · 2025Article
- Exploring the hypothetical role of cerebellar pain prediction errors in fibromyalgia-associated chronic pain.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibromyalgia (FM) is a chronic pain condition that predominantly affects women. Evidence implies that FM is associated with dysfunction of the central nervous system (CNS). In this study, we investigated the structural differences between FM patients and healthy control (HC) subjects using a multivariate approach. Source-based morphometry (SBM) was applied to structural magnetic resonance imaging (sMRI) data consisting of 20 FM patients (46.4 ± 12.5), and age and gender-matched 20 HC subjects (42.1 ± 12.5). SBM revealed greater grey matter volume (GMV) in the bilateral thalamus in FM patients. Conversely, lower GMV was found in the bilateral putamen, bilateral pallidum, right cerebellum, right calcarine, right amygdala, and bilateral insula in FM patients. Further analysis indicated that grey matter deficits in the pallidum were significantly associated with pain catastrophizing, pain magnification, rumination, and feelings of helplessness, suggesting a link between structural brain changes and clinical pain metrics. These findings provide new insights into the neurobiological underpinnings of FM, highlighting the role of specific brain regions in pain processing and emotional regulation. The results underscore the potential for targeted therapeutic interventions that address both the neurobiological and psychological aspects of FM, paving the way for more effective management strategies for this complex condition.
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