Evidence map›Paper›PMID 40393890›Full record

ReviewTrends in parasitology2025

Var genes, strain hyperdiversity, and malaria transmission dynamics.

Karen P Day, Mun Hua Tan, Qixin He, Shazia Ruybal-Pesántez, Qi Zhan, Kathryn E Tiedje, Mercedes Pascual

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in parasitology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Karen P DayDepartment of Microbiology and Immunology, Bio21 Institute and The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, VIC, Australia. Electronic address: karen.day@unimelb.edu.au.
Mun Hua TanDepartment of Microbiology and Immunology, Bio21 Institute and The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, VIC, Australia.
Qixin HeDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Shazia Ruybal-PesántezMRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Qi ZhanCommittee on Genetics, Genomics and Systems Biology, The University of Chicago, Chicago, IL, USA.
Kathryn E TiedjeDepartment of Microbiology and Immunology, Bio21 Institute and The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, VIC, Australia.
Mercedes PascualDepartment of Biology and Department of Environmental Studies, New York University, New York, NY, USA.

Funding

Temporal strain structure and response to interventions in a high endemicity region of Plasmodium falciparum R01AI149779 · NIAID · UNIVERSITY OF CHICAGO · PI DAY, KAREN PATRICIA, KORAM, KWADWO ANSAH · 2019 to 2023
$3.0M
P.falciparum var gene diversity and malaria controlR01AI084156 · NIAID · UNIVERSITY OF MELBOURNE · PI DAY, KAREN PATRICIA · 2010 to 2014
$1.9M
The impact of seasonality and vector control on the population structure of Plasmodium falciparumR01TW009670 · FIC · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAY, KAREN PATRICIA, KORAM, KWADWO ANSAH · 2013 to 2016
$1.8M
FIC NIH HHS R01 TW009670NIAID NIH HHS R01 AI084156NIAID NIH HHS R01 AI149779
6 · The paper itself

Abstract

The microbiological paradigm for surveillance of diverse pathogens requires knowledge of the variation of the major surface antigen under the most intense immune selection as immune responses to these antigens drive transmission dynamics. This creates a pathway for population genetics/genomics to be combined with mathematical modelling to describe transmission dynamics to inform public health policy. Here we consider how we can bring population genetics and population dynamics together for a highly recombining pathogen like Plasmodium falciparum. We do this through the lens of what has been recently learnt about the population genetics of the var multigene family encoding the major surface antigen of the blood stages of Plasmodium falciparum, known as PfEMP1.

Indexed as

Genetic VariationMalaria, FalciparumPlasmodium falciparumProtozoan ProteinsAnimalsHumanserythrocyte membrane protein 1, Plasmodium falciparumProtozoan ProteinsPlasmodium falciparumpopulation geneticsstrain diversitytransmission dynamicsvariant antigen genes

Identifiers

PMID40393890
PMCPMC12416208

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.