Evidence map›Paper›PMID 40393889›Full record

ReviewTrends in immunology2025

Evolutionarily ancient functions of enzymatic TIR proteins in innate immunity.

Khursheed A Wani, Read Pukkila-Worley

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Khursheed A WaniDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA. Electronic address: Khursheed.Wani@umassmed.edu.
Read Pukkila-WorleyDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA. Electronic address: Read.Pukkila-Worley@umassmed.edu.

Funding

An Immune Surveillance Network in C. elegansR01AI130289 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PUKKILA-WORLEY, READ · 2017 to 2025
$4.6M
Sensing bacterial patterns of pathogenesis by an enzymatic TIR proteinR01AI159159 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Read Pukkila-Worley · 2021 to 2026
$3.7M
Neuroendocrine regulation of intestinal epithelial immunity in C. elegansR21AI163430 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PUKKILA-WORLEY, READ · 2021 to 2022
$461k
NIAID NIH HHS R01 AI130289NIAID NIH HHS R01 AI159159NIAID NIH HHS R21 AI163430
6 · The paper itself

Abstract

Proteins with a Toll/interleukin-1 receptor/resistance (TIR) domain are among the most ancient immune regulators and include well-known pattern recognition receptors (PRRs). A specialized subset of TIR domain proteins are enzymes that predominantly use nicotinamide adenine dinucleotide (NAD

Indexed as

Immunity, InnateReceptors, Interleukin-1AnimalsBacteriaEvolution, MolecularHumansPlantsReceptors, Pattern RecognitionReceptors, Interleukin-1Receptors, Pattern Recognitioneffector-triggered immunityenzymatic TIR proteinsinnate immunityNAD+SARM1

Identifiers

PMID40393889
PMCPMC13059133

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.