ReviewGenes & development2025
Molecular mechanisms and neural mediators of leptin action.
Review in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Global Research Landscape on Leptin Resistance and Obesity-Related Metabolic Dysfunction: Trends, Networks and Visualisation Analysis (1995-2025).Endocrinology, diabetes & metabolism · 2026Review
- Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.Current obesity reports · 2026Review
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.Metabolism: clinical and experimental · 2026Article
- Increased leptin signaling drives the response of hypothalamic LepRb neurons to diet-induced obesity.Molecular metabolism · 2026Article
- Molecularly defined subpopulations of leptin receptor neurons dissociate the control of food intake from blood pressure.bioRxiv : the preprint server for biology · 2026Article
- Leptin Receptor b (LEPRb) Mutations Disrupt Hypothalamic Control of the Reproductive Axis.International journal of molecular sciences · 2026Review
- Gestational diabetes mellitus-induced adipokine dysregulation and links to metabolic programming risks.Frontiers in endocrinology · 2026Observational
- Food additives with aldehyde skeleton exhibited leptin resistance in cells.Frontiers in nutrition · 2026Article
- Obesity and hepatic steatosis in STAT3 hyper-IgE syndrome.The journal of allergy and clinical immunology. In practice · 2026Article
- Tirzepatide Synergizes with Leptin on Weight Loss and Restoring Metabolic Homeostasis in Diet-induced Obesity Model.bioRxiv : the preprint server for biology · 2025Article
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.bioRxiv : the preprint server for biology · 2025Article
- Association Between Obesity and Serum Leptin Levels in Brazilian Female Shift Workers.Diseases (Basel, Switzerland) · 2025Article
- Leptin-Independent Association Between SNVs in the Leptin Gene and HDL-C and Apo-AI in Children.International journal of molecular sciences · 2025Article
- Leptin and G-protein coupled receptor (GPCR) signaling: Therapeutic potential in obesity.The Journal of biological chemistry · 2025Review
- Unraveling the Obesogenic Mechanism of Bisphenol A Through Network Toxicology and Molecular Docking: Identification of Key Molecular Targets.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The adipose-derived hormone leptin signals the adequacy of body triglyceride stores to specialized leptin receptor (LepRb)-containing cells, which modulate physiology and behavior appropriately for the status of energy reserves. Decreased leptin action initiates a program that restrains a host of energy-intensive processes, promotes food seeking and consumption, and supports the continued availability of glucose and other metabolic fuels in the face of diminished fat stores. In addition to activating the STAT3-dependent transcriptional regulation that mediates most leptin action in vivo, LepRb mediates some leptin effects via a poorly understood second intracellular signaling pathway. Leptin also activates feedback pathways that restrain LepRb signaling in the face of high leptin, as in obesity. Leptin mediates most of its metabolic effects via multiple populations of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.