ArticleJournal of the National Cancer Institute2025
Leisure-time physical activity after diagnosis and survival by cancer type: a pooled analysis.
Article in Journal of the National Cancer Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Post-diagnosis physical activity in relation to mortality among gynecological cancer survivors.Cancer causes & control : CCC · 2026Pooled it
- Post-diagnosis physical activity in relation to mortality among prostate cancer survivors: a systematic review and meta-analysis.Cancer causes & control : CCC · 2026Pooled it
- Understanding the Effects of Cancer-Related Factors on the Association Between Physical Activity and Quality of Life in Breast Cancer Survivors.Journal of physical activity & health · 2026Trial
- Physical health outcomes and step cadence improvements: a digital physical activity intervention in cancer survivors.JNCI cancer spectrum · 2025Trial
- Exercise therapy in cancer prevention and treatment.Nature reviews. Clinical oncology · 2026Review
- Prevalence of meeting aerobic physical activity and resistance training guidelines in advanced prostate cancer: a descriptive study of racial and regional disparities in the IRONMAN registry.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Association Between Physical Activity and Mortality in Men with or at Risk of Prostate Cancer: A Systematic Review.Healthcare (Basel, Switzerland) · 2026Review
- Exercise, Cellular Senescence, and Cancer: Novel Perspectives on Functional Aging Through Block Strength Training in Older Adults-A Narrative Review.Biomedicines · 2026Review
- Leisure-Time Physical Activity and Cancer Mortality Among Cancer Survivors.JAMA network open · 2026Article
- Training gut and body: physical activity, diet, ASA and microbiota influence the outcome in gastrointestinal cancer survivors.Frontiers in nutrition · 2025Review
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundEvidence for potential mortality benefits of leisure-time moderate-to-vigorous intensity physical activity (MVPA) for survivors of cancer types beyond breast and colorectal is limited. The aim of this study was to evaluate relationships between postdiagnosis MVPA and all-cause mortality in participants with a history of 11 cancer types.
methodsData were pooled from 6 United States-based cohort studies. Cohort-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for associations of MVPA assessed ≥1 year after a cancer diagnosis and all-cause mortality were calculated using multivariable Cox proportional hazards models and then pooled using random effects meta-analysis. Models were adjusted for age, sex, race/ethnicity, smoking status, alcohol use, and cancer treatment and stage. The sample included 90 844 cancer survivors (mean [standard deviation] age at diagnosis = 67 [10] years, 55% women), among whom 45 477 died during 10.9 [7.0] years of follow-up.
resultsCompared with no MVPA, engaging in recommended amounts of MVPA (7.5 to <15 MET-hr/wk) was related to better overall survival in participants with a history of 1 of 10 cancer types: oral (HR = 0.44, 95% CI = 0.27 to 0.73), endometrial (0.50, 95% CI = 0.34 to 0.76), lung (0.51, 95% CI = 0.38 to 0.68), rectal (0.51, 95% CI = 0.36 to 0.71), respiratory (0.51, 95% CI = 0.29 to 0.72), bladder (0.53, 95% CI = 0.40 to 0.72), kidney (0.53, 95% CI = 0.37 to 0.77), prostate (0.60,95% CI = 0.49 to 0.74), colon (0.61, 95% CI = 0.50 to 0.76), and breast (0.67, 95% CI = 0.55 to 0.81). Eight of the 10 observed inverse associations remained similar when excluding participants who died within 2 years of follow-up.
conclusionEngaging in leisure-time MVPA after a cancer diagnosis appears to improve survival for people with a history of several cancer types, including bladder, breast, colon, endometrial, kidney, lung, oral, prostate, rectal, and respiratory cancer.
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