Evidence map›Paper›PMID 40393125›Full record

ArticleNuclear medicine and biology

Enhancing the therapeutic index of [

Truc T Huynh, Yutian Feng, Rebecca L Banks, Ganesan Vaidyanathan, Michael R Zalutsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. First-in-human evaluation of [European journal of nuclear medicine and molecular imaging · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Truc T HuynhDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Yutian FengDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Rebecca L BanksDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Ganesan VaidyanathanDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Michael R ZalutskyDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: zalut001@mc.duke.edu.

Funding

Small Molecule PSMA-Targeted Alpha TherapyR01CA184228 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI POMPER, MARTIN G, ZALUTSKY, MICHAEL ROD · 2014 to 2023
$3.6M
PSMAi-PARPi combination agents for the targeted Auger and alpha therapy of metastatic castration-resistant prostate cancerR21CA274271 · NCI · DUKE UNIVERSITY · PI ZALUTSKY, MICHAEL ROD · 2022 to 2022
$414k
NCI NIH HHS R01 CA184228NCI NIH HHS R21 CA274271
6 · The paper itself

Abstract

introductionLow-molecular-weight (LMW) PSMA-targeted agents have enjoyed success; however, their off-target toxicity in normal tissues such as kidneys, salivary gland and lacrimal gland can be dose limiting. Herein, we have evaluated the effect of co-administration of the non-radioactive iodo pseudo carrier, iodo YF2, on the normal tissue uptake of [

methods[

resultsAt 1 h, no significant difference was seen in kidney uptake of [

conclusionsCo-administration of iodo YF2 reduced kidney uptake of [

Indexed as

Glutamic AcidKidneyLacrimal ApparatusRadiopharmaceuticalsSalivary GlandsAnimalsAstatineCell Line, TumorHumansMaleMiceMolecular WeightOrgan SpecificityProstatic NeoplasmsAstatineAstatine-211Glutamic AcidRadiopharmaceuticals(211)Astatine[(211)At]YF2Prostate cancerProstate-specific membrane antigenRadionuclide therapy

Identifiers

PMID40393125
PMCPMC12353925

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.