Evidence map›Paper›PMID 40393065›Full record

ArticleLupus2025

Hypertension, proteinuria, and RAAS inhibition use in children with systemic lupus erythematosus: Data from a multi-institutional pediatric learning health system.

Joyce C Chang, Meredith A Atkinson, Amy Goodwin Davies, Mitchell Maltenfort, Ingrid Y Luna, Hanieh Razzaghi, Vikas R Dharnidharka, Joseph T Flynn, William E Smoyer, Mark M Mitsnefes and 8 more

Abstract readControlled Clinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lupus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Joyce C ChangDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1691-4814
Meredith A AtkinsonDivision of Pediatric Nephrology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Amy Goodwin DaviesApplied Clinical Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Mitchell MaltenfortApplied Clinical Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ingrid Y LunaApplied Clinical Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Hanieh RazzaghiApplied Clinical Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Vikas R DharnidharkaDivision of Pediatric Nephrology, Hypertension and Apheresis, Washington University and St Louis Children's Hospital, St Louis, MO, USA.
Joseph T FlynnDepartment of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
William E SmoyerDepartment of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA.
Mark M MitsnefesDivision of Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Bradley P DixonDepartment of Pediatric Nephrology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA.
Caroline A GluckDivision of Pediatric Nephrology, Sidney Kimmel Medical College at Thomas Jefferson University, Nemours Children's Health, Wilmington, DE, USA.
Rebecca ScobellPerelman School of Medicine at the University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
L Charles BaileyPerelman School of Medicine at the University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Susan L FurthPerelman School of Medicine at the University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Christopher B ForrestPerelman School of Medicine at the University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Michelle R DenburgPerelman School of Medicine at the University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Scott E WenderferPediatric Nephrology, University of British Columbia, BC Children's Hospital, Vancouver, CA, USA.ORCID 0000-0002-8991-8277

Funding

Research Project Core 2P50DK114786 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI Michelle Denburg, SUSAN L. FURTH · 2017 to 2026
$9.6M
Cardiovascular health assessment & outcomes of systemic lupus erythematosus: bridging pediatric and adult-onset diseaseK23HL148539 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI CHANG, JOYCE CHUN-LING · 2020 to 2024
$973k
NHLBI NIH HHS K23 HL148539NIDDK NIH HHS P50 DK114786
6 · The paper itself

Abstract

ObjectivesTo assess the potential of a multi-institutional pediatric learning health system for comparative effectiveness research in pediatric-onset systemic lupus erythematosus (SLE), we characterized renin angiotensin aldosterone system (RAAS) inhibitor utilization and the feasibility of ascertaining key treatment indications and outcomes, including hypertension and proteinuria.MethodsWe identified children with SLE and lupus nephritis (LN) at 6 PEDSnet institutions using previously developed computable phenotypes. A reference population of controls without SLE was randomly sampled from the same rheumatology/nephrology clinics (

Indexed as

Angiotensin-Converting Enzyme InhibitorsHypertensionLupus Erythematosus, SystemicLupus NephritisProteinuriaRenin-Angiotensin SystemAdolescentBlood PressureCase-Control StudiesChildFemaleHumansMaleAngiotensin-Converting Enzyme Inhibitorscardiovascular diseaserenal lupusSystemic lupus erythematosus

Identifiers

PMID40393065
PMCPMC12185231

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.