ArticleOrganic letters2025
Synthesis of Nonsymmetrical 3,3'-Bicoumarins: Total Synthesis of Arteminorin C, 3,3'-Biisofraxidin, and Biscopoletin.
Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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Authors and funding
4 authors.
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Abstract
A strategy to access nonsymmetrical 3,3'-bicoumarins employing two consecutive Perkin reactions is reported. This approach is based on the initial formation of coumarin acetic acid from a salicylaldehyde derivative through a Perkin reaction. A second Perkin condensation between the previously formed coumarin acetic acid and a new functionalized salicylaldehyde allows the formation of nonsymmetrical 3,3'-bicoumarins. Using this approach, 17 nonsymmetrical and two symmetrical 3,3'-bicoumarins were prepared in yields ranging from 30% to 86%, and natural products arteminorin C, 3,3'-biisofraxidin, and biscopoletin were obtained.
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