Trial reportPloS one2025
Improvement in quality of life and cognitive function in Post-COVID syndrome after online occupational therapy: Results from a randomized controlled pilot study.
Trial report in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Longitudinal observation of persistent Long COVID symptoms and health-related quality of life in an adult German cohort.BMC infectious diseases · 2026Observational
- Two-timepoint multidomain follow-up of post-COVID condition and ME/CFS: overlapping autonomic, small-fiber, and cognitive changes.Journal of translational medicine · 2026Article
- App-based self-management program for people dealing with fatigue and trouble concentrating (DiEgO): protocol for participatory development, pilot testing, and qualitative process evaluation.Pilot and feasibility studies · 2026Article
- Beyond COVID-19 Infection: Cognitive and Emotional Pathways Between Posttraumatic Stress, Rumination, and Quality of Life in Hospitalized Patients.Healthcare (Basel, Switzerland) · 2025Article
- Use of wearables to measure the effects of long COVID on activities of daily living and their relationship to perceived exertion, occupational performance, and quality of life.Frontiers in public health · 2025Observational
- Acceptability of Telehealth-Delivered Occupational Therapy Among Individuals With Long COVID Using the Theoretical Framework of Acceptability: A Qualitative Study.International journal of telemedicine and applications · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-COVID syndrome (PCS) poses enormous clinical challenges. Occupational therapy (OT) is recommended in PCS, but structural validation of this concept is pending.
methodsIn an unblinded randomized pilot study (clinical trial # DRKS0026007), feasibility and effects of online OT in PCS were tested. Probands received structured online OT over 12 weeks either via interactive online treatment sessions (interactive group) or prerecorded videos (video group). 50% of probands received no online OT (control group). At week 0, 12, and 24, we analyzed study experience, health-related quality of life, cognitive functions. impairment in performance, and social participation.
resultsN = 158 probands (mean age 38 yrs., 86% female) were included into the analyses. The study experience was described as positive or very positive in 83.3% of probands in the interactive versus 48.1% of probands in the video group (p = 0.001). After 12 weeks, all groups displayed significant improvement in concentration, memory, and performance of daily tasks. After 24 weeks, significant improvement in concentration and memory were observed in control- and video-probands, and social participation had improved after video-OT. However, only probands in the interactive online OT group showed improvement of all measured endpoints including concentration, memory, quality of life, and social participation.
conclusionWe show that online OT is feasible, and that interactive online OT is a promising treatment strategy for affected patients. We present exploratory data on its efficacy and describe variables that can be employed for further investigations in confirmatory trials.
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