Evidence map›Paper›PMID 40392869›Full record

ArticlePloS one2025

Modeling and computational study of cancer treatment with radiotherapy using real data.

Parvaiz Ahmad Naik, Muhammad Farman, Saba Jamil, Muhammad Umer Saleem, Kottakkaran Sooppy Nisar, Zhengxin Huang

Abstract read
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Parvaiz Ahmad NaikDepartment of Mathematics and Computer Science, Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Muhammad FarmanArt and Science Faculty, Department of Mathematics, Near East University, Boulevard, Nicosia/Mersin, Turkey.
Saba JamilInstitute of Mathematics, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan, Pakistan.
Muhammad Umer SaleemDepartment of Mathematics, University of Education, Lahore, Pakistan.
Kottakkaran Sooppy NisarDepartment of Mathematics, College of Science and Humanities, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia.
Zhengxin HuangDepartment of Mathematics and Computer Science, Youjiang Medical University for Nationalities, Baise, Guangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The numerical simulation of biological processes with non-integer ordering is attracting an increasing amount of interest from scientists and academics. Traditional biological systems can be presented in a fixed order, but fractional-order derivative systems are not considered stable orders. When the fractional derivative has a non-fixed order, it becomes more useful for simulating real-world problems. In this paper, we aim to study the dynamics of a novel technique that we propose, implement, and use in a radiation model for the treatment of cancer. We present some intriguing results for the cancer treatment fractal fractional model in the context of this innovative operator. Research has been done on the cancer model in both qualitative and quantitative manners. The first and second derivatives of the Lyapunov function are used to analyze the stability of the cancer fractal fractional model. Using the linear growth theory, the existence of a unique solution has been derived under the FFM. Lagrangian-piece-wise interpolation has been used to obtain numerical results for various fractal-fractional operators. The fractal fractional model was used to simulate the treatment process of three patients. Different values of fractional order [Formula: see text], fractal dimension [Formula: see text], and other parameter values have been used to show the graphs. Additionally, we looked at how radiation changed both healthy cells and malignant cells over time. The study confirmed the effectiveness of radiation medicine against populations as well as the occurrence of the memory effect during [Formula: see text] and [Formula: see text] transitions from 1. A biological process requires fractal-fractional processes which provide superior modeling capabilities compared to traditional fractional operators as well as classical operators. This research brings novel significance through its implementation of fractal-fractional operators as they provide a superior approach to model cancer treatment processes by better representing biological system complexities. Standard modeling systems cannot reproduce both important memory dynamics together with non-local communication patterns which play essential roles in cancer development and treatment analysis. The implementation of fractal-fractional derivatives enables our model to produce a more realistic representation of cancer cell and healthy cell radiotherapy responses throughout time. Our study has upgraded theoretical cancer dynamic analysis and developed optimized treatment methods for customization purposes. Wider understanding of cancer cell reactions to treatments enables healthcare providers to adopt personalized strategies that produce superior recovery outcomes for their patients. The model acquires stability strength through Lyapunov functions analysis to create a solid scientific foundation in oncology research.

Indexed as

Computer SimulationModels, BiologicalNeoplasmsFractalsHumans

Identifiers

PMID40392869
PMCPMC12091799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.