Evidence map›Paper›PMID 40392848›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Arteries are finely tuned thermosensors regulating myogenic tone and blood flow.

Thieu X Phan, Niaz Sahibzada, Marc Freichel, Rosa L Miyares, Gerard P Ahern

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Thieu X PhanDepartment of Pharmacology and Physiology, Georgetown University, Washington DC 20007.
Niaz SahibzadaDepartment of Pharmacology and Physiology, Georgetown University, Washington DC 20007.ORCID 0000-0002-4169-370X
Marc FreichelDepartment of General Pharmacology, Pharmakologisches Institut, Universität Heidelberg, Heidelberg D-69120, Germany.ORCID 0000-0003-1387-2636
Rosa L MiyaresDepartment of Pharmacology and Physiology, Georgetown University, Washington DC 20007.
Gerard P AhernDepartment of Pharmacology and Physiology, Georgetown University, Washington DC 20007.ORCID 0000-0001-5317-7262

Funding

TRPV1 and the regulation of arterial toneR01HL155979 · NHLBI · GEORGETOWN UNIVERSITY · PI AHERN, GERARD P · 2021 to 2024
$1.6M
NHLBI NIH HHS R01 HL155979
6 · The paper itself

Abstract

In response to changing blood pressure, arteries adjust their caliber to control blood flow. This vital autoregulatory property, termed vascular myogenic tone, stabilizes downstream capillary pressure. Here, we reveal that tissue temperature, combined with intraluminal pressure, critically determines myogenic tone. Heating steeply activates tone in skeletal muscle, gut, brain, and skin arteries with temperature coefficients (

Indexed as

ArteriesMuscle, SkeletalRegional Blood FlowAnimalsMaleMembrane PotentialsMiceMice, Inbred C57BLMuscle TonusPerfusionTemperatureThermosensingTRPM Cation ChannelsTRPV Cation ChannelsTRPM4 protein, mouseTRPM Cation ChannelsTRPV1 protein, mouseTRPV Cation Channelsblood flowmyogenic tonetemperatureTRP channels

Identifiers

PMID40392848
PMCPMC12130814

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.