SynthesisPloS one2025
Comparative effects of transcatheter versus surgical pulmonary valve replacement: A systematic review and meta-analysis.
Synthesis in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Management of prosthetic pulmonary valve endocarditis should include the selective application of transcatheter pulmonary valve replacement.JTCVS structural and endovascular · 2026Article
- Exploring the application value of preoperative femoral artery and vein cannulation in redo cardiac surgery.Journal of cardiothoracic surgery · 2026Article
- Comparative Outcomes of Transcatheter Versus Surgical Pulmonary Valve Replacement in Adults With Congenital Heart Disease.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- One Anatomy, Multiple Valve Choices: Interobserver Agreement in Selecting Transcatheter Pulmonary Valve.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- Structural Heart Interventions in Women with Congenital Heart Disease.Current cardiology reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTranscatheter pulmonary valve replacement (TPVR) is developed as a non-surgical, minimally invasive procedure to reduce the need for re-do cardiac surgical interventions. However, its impacts on patient outcomes are less clear. This study aims to investigate the effects of TPVR among patients with pulmonary valve or right ventricular outflow tract dysfunctions. MATERIALS AND
methodsIn this systematic review and meta-analysis, we searched PubMed, Cochrane CENTRAL, EMBASE, CINAHL Complete, and Web of Science, from database inception to March 1, 2024, to identify studies that assessed the comparative effectiveness of transcatheter pulmonary valve replacement (TPVR) and surgical pulmonary valve replacement (SPVR). The key outcomes of interest included mortality, pulmonary regurgitation (PR), infective endocarditis (IE), re-intervention, improvements in cardiac failure based on the New York Heart Association (NYHA) functional classification, and adverse events. Meta-analyses using a random-effects model were performed.
resultsA total of 28 studies (n = 16,150) were included. The meta-analyses depicted that when compared with SPVR, TPVR reduced risks of mortality by 36% (odds ratio [OR] = 0.64 [95% confidence interval, CI: 0.43, 0.95]), but conferred a three-fold greater odd of IE over the follow-up duration (OR = 3.10 [95% CI: 2.22, 4.33]). No significant differences were observed for 30-day mortality, and the early PR, IE and re-intervention, as well as the PR and re-intervention during follow-up. Meta-analyzed results across the outcome measures varied according to geographical region, publication year cut-off, and income status of country. All patients who had undergone valve replacement showed improvements in heart function and experienced relevant post-procedural complications.
conclusionsTPVR afforded significant clinical benefits in patient survival, but nonetheless, it was associated with an elevated risk for infective endocarditis.
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