Evidence map›Paper›PMID 40392706›Full record

ArticleAIDS patient care and STDs2025

Universal "Test and Treat" for HIV Had Little Effect on Outcomes, but Missed Clinic Visits Threaten Success of Botswana's National Antiretroviral Treatment Program.

Lentlametse Mantshonyane, Joseph Jarvis, Bogadi Loabile, Marlene B Nkete, Ronald Monnaatlala, Gaone Makwinja Mmolai, Atlasaone Mosomodi, Robert Gross

Abstract read
In one paragraph

Article in AIDS patient care and STDs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lentlametse MantshonyaneDepartment of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-5785-6809
Joseph JarvisLondon School of Hygiene & Tropical Medicine, London, United Kingdom.
Bogadi LoabileBotswana Upenn-Partnership, Gaborone, Botswana.
Marlene B NketeTebelopele Voluntary Counseling &Testing Center Gaborone, Gaborone, Botswana.
Ronald MonnaatlalaTebelopele Voluntary Counseling &Testing Center Gaborone, Gaborone, Botswana.
Gaone Makwinja MmolaiTebelopele Voluntary Counseling &Testing Center Gaborone, Gaborone, Botswana.
Atlasaone MosomodiMinistry of Health-Botswana National Health Laboratory Gaborone, Gaborone, Botswana.
Robert GrossUniversity of Pennsylvania-Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ronald G Collman · 1999 to 2026
$78.6M
Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Karine Dube, Kelly L Jordan-Sciutto · 2013 to 2026
$23.5M
NIAID NIH HHS P30 AI045008NIMH NIH HHS P30 MH097488
6 · The paper itself

Abstract

In 2016, Botswana changed the policy to institute universal "test and treat" (UTT) in people with human immunodeficiency virus or HIV (PWH). It is unclear whether these policy changes have yielded any clinical benefits or harms. We conducted a retrospective cohort analysis of PWH aged ≥18 years to compare patient outcomes in individuals who received antiretroviral treatment (ART) under (1) the introduction of UTT and (2) rapid versus delayed ART start, at two clinics in Gaborone, Botswana, between 2014 and 2020. Multivariate logistic regression and propensity score models were used to control for potential confounding and selection bias. Of the 2008 participants who had a complete plasma HIV RNA at 1 year following ART initiation, 59 (2.9%) experienced virologic failure, and 665 (33.1%) were lost to follow-up (LTFU). Higher LTFU was recorded in UTT than in delayed ART period (43% vs 31%,

Indexed as

Anti-HIV AgentsHIV InfectionsHIV TestingAdultAmbulatory Care FacilitiesBotswanaCD4 Lymphocyte CountFemaleHumansLost to Follow-UpMaleMiddle AgedRetrospective StudiesRNA, ViralTreatment OutcomeViral LoadAnti-HIV AgentsRNA, Viralantiretroviral therapyloss to follow-uprapid ARTuniversal test and treatvirologic failure

Identifiers

PMID40392706
PMCPMC12172638

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.