Evidence map›Paper›PMID 40392585›Full record

ArticleLab on a chip2025

Human mesofluidic intestinal model for studying transport of drug carriers and bacteria through a live mucosal barrier.

Chia-Ming Wang, Hardeep S Oberoi, Devalina Law, Yuan Li, Timothy Kassis, Linda G Griffith, David T Breault, Rebecca L Carrier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lab on a chip, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Chia-Ming WangDepartment of Bioengineering, Northeastern University, Boston, MA, 02115, USA. r.carrier@northeastern.edu.ORCID 0009-0007-0016-600X
Hardeep S OberoiNCE-Formulation Sciences, Abbvie Inc., North Chicago, IL, 60064, USA.
Devalina LawNCE-Formulation Sciences, Abbvie Inc., North Chicago, IL, 60064, USA.
Yuan LiDepartment of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA.
Timothy KassisDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Linda G GriffithDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
David T BreaultDivision of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.
Rebecca L CarrierDepartment of Bioengineering, Northeastern University, Boston, MA, 02115, USA. r.carrier@northeastern.edu.

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
GuMI: New In Vitro Platforms to Parse the Human Gut Epithelial-Microbiome-Immune AxisR01EB021908 · NIBIB · NORTHEASTERN UNIVERSITY · PI CARRIER, REBECCA L, GRIFFITH, LINDA G · 2016 to 2020
$5.2M
Impact of Lipids on Compound Absorption: Mechanistic Studies and ModelingR01GM098117 · NIGMS · NORTHEASTERN UNIVERSITY · PI CARRIER, REBECCA L · 2012 to 2021
$3.3M
Impact of lipids and food on oral compound absorption: mechanistic studies and modelingR35GM153324 · NIGMS · NORTHEASTERN UNIVERSITY · PI Rebecca L Carrier · 2024 to 2026
$1.3M
NIBIB NIH HHS R01 EB021908NIDDK NIH HHS P30 DK034854NIGMS NIH HHS R01 GM098117NIGMS NIH HHS R35 GM153324
6 · The paper itself

Abstract

The intestinal mucosal barrier forms a critical interface between lumen contents such as bacteria, drugs, and drug carriers and the underlying tissue. Current

Indexed as

Drug CarriersEscherichia coliIntestinal MucosaLab-On-A-Chip DevicesModels, BiologicalBiological TransportHumansMucusDrug Carriers

Identifiers

PMID40392585
PMCPMC12091270

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.