Evidence map›Paper›PMID 40392535›Full record

Trial reportJournal of orthopaedic research : official publication of the Orthopaedic Research Society2025

Peak Vertical Ground Reaction Force Modifies Gait Biomechanics Bilaterally Following ACL Reconstruction: A Randomized Experiment.

Elizabeth Bjornsen, Alyssa Evans-Pickett, Hope Davis-Wilson, Amanda E Munsch, J Troy Blackburn, Jason R Franz, Todd A Schwartz, Jeffrey Spang, Brian Pietrosimone

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Gait Biomechanical Profiles Following Anterior Cruciate Ligament Reconstruction in Sexually-Immature Pediatrics.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elizabeth BjornsenHuman Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-8824-9366
Alyssa Evans-PickettHuman Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Hope Davis-WilsonRTI International, Research Triangle Park, North Carolina, USA.
Amanda E MunschJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, USA.
J Troy BlackburnDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0003-0878-9432
Jason R FranzJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, USA.
Todd A SchwartzDepartment of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA.
Jeffrey SpangDepartment of Orthopedics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Brian PietrosimoneDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Funding

Improving Disability in Knee Osteoarthritis by Targeting Neuromuscular DeficitsR21AR067560 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PIETROSIMONE, BRIAN · 2015 to 2016
$368k
In vivo Manipulation of Mechanical Loading: Using Real-time Biofeedback to Strategically Understand the Acute Biomechanical, Biochemical and Structural Changes Induced by Lower Extremity LoadingR21AR074094 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANZ, JASON R, PIETROSIMONE, BRIAN · 2018 to 2019
$357k
Posttraumatic Osteoarthritis: Establishing a Comprehensive Evaluation StrategyR03AR066840 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PIETROSIMONE, BRIAN · 2015 to 2016
$152k
NIAMS NIH HHS R03 AR066840NIAMS NIH HHS R21 AR067560NIAMS NIH HHS R21 AR074094The research in the enclosed article was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (1R21AR067560-01; R21 AR074094; 1R03AR066840-01A1), North Carolina Translational and Clinical Sciences Institute, National Athletic Trainers Association Research and Education Foundation (NATAREF NIA 0001).
6 · The paper itself

Abstract

Vertical ground reaction force (vGRF) is a promising target for modifying aberrant gait biomechanics in individuals post-anterior cruciate ligament reconstruction (ACLR). However, an adequate sample size and arandomized, mechanistic study is needed to determine acute effects of vGRF biofeedback on biomechanical outcomes. The purpose of the study is to determine differences in discrete gait biomechanical variables (i.e., first and second peak vGRF, midstance vGRF, peak knee flexion angle (KFA), KFA range-of-motion (ROM), peak knee extension moment (KEM), and peak knee abduction moment (KAM) following a treadmill walking protocol between limbs and across four separate conditions in individuals 6-12 months post-ACLR. We utilized a randomized, cross-over mechanistic trial where participants walked for 3000 steps for three visual feedback conditions (i.e., HIGH, LOW, and SYMMETRICAL vGRF loading) and a control condition on a dual-belt treadmill. We constructed a mixed effects linear model to determine within-subject biomechanical changes between limbs and conditions. The HIGH condition elicited greater first peak vGRF, sagittal plane motion (i.e., peak KFA, KFA ROM), and peak KEM compared to the control condition (p < 0.01). The LOW condition observed first peak vGRF and KFA ROM decreases but increased peak KFA and KEM (p < 0.01) compared to the control condition. No notable biomechanical changes were observed between the SYMMETRICAL and control conditions. The HIGH condition produced acute, sagittal plane kinematic and kinetic profile improvements in ACLR individuals. vGRF is a viable target for modifying gait biomechanics; future work should determine the long-term health effects of vGRF-driven feedback treatment to improve gait profiles post-ACLR.

Indexed as

Anterior Cruciate Ligament ReconstructionGaitAdultAnterior Cruciate Ligament InjuriesBiomechanical PhenomenaCross-Over StudiesFemaleHumansKnee JointMaleRange of Motion, ArticularYoung Adultanterior cruciate ligament reconstructiongait retrainingreal‐time biofeedbackvertical ground reaction forcevisual biofeedback

Identifiers

PMID40392535
PMCPMC12259355

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.