ArticleDrug delivery and translational research2026
Development of a hydrophilic transdermal patch for combined delivery of sumatriptan and metoclopramide in migraine therapy.
Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Design of Experiments in the Formulation and Characterization of 3D-Printed Vaginal Films Loaded with Curcumin Solid Lipid Nanoparticles for Cervical Dysplasia.Pharmaceuticals (Basel, Switzerland) · 2026Article
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Abstract
Migraine, a prevalent neurological disorder, is known to significantly impact patients' quality of life. The effectiveness of oral medications is often hindered by nausea and vomiting, common migraine symptoms. In this study, a transdermal patch for the co-delivery of sumatriptan succinate and metoclopramide HCl was developed and evaluated, to offer a patient-friendly alternative for migraine management. This study evaluated the impact of chemical enhancers and hydrophilic formulations on drug permeation using dermatomed porcine ear skin. A combination of 25% w/w propylene glycol (PG) and 10% w/w dimethyl isosorbide (DMI) significantly enhanced the permeation of both drugs. Among four hydrophilic patch formulations, a matrix composed of a 1:3 ratio of polyvinylpyrrolidone (PVP) to hydroxypropyl methylcellulose (HPMC) demonstrated optimal drug delivery. Characterization tests, including coat weight, drug content uniformity, tack testing, and slide crystallization, were performed, all patches exhibited acceptable physical properties, including uniform drug content. The target therapeutic dose, equivalent to 4 mg subcutaneous injection of sumatriptan succinate and 10 mg oral metoclopramide HCL, was achieved within 8 h using a 60 cm
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