Evidence map›Paper›PMID 40392463›Full record

ArticleInternational journal of hematology2025

Impact of center volume on acute graft versus host disease in allogeneic stem cell transplant recipients.

Yoshimitsu Shimomura, Seitaro Terakura, Keitaro Matsuo, Yuri Ito, Tatsuo Ichinohe, Yoshiko Hashii, Hideki Goto, Koji Kato, Koji Kawamura, Makoto Onizuka and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yoshimitsu ShimomuraDepartment of Hematology, Kobe City Hospital Organization Kobe City Medical Center General Hospital, Minamimati 2-1-1, Minatojima, Chuo-ku, Kobe, 650-0047, Japan. shimomura_0119@yahoo.co.jp.ORCID http://orcid.org/0000-0003-1018-9508
Seitaro TerakuraDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
Keitaro MatsuoDivision Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.
Yuri ItoDepartment of Medical Statistics, Research & Development Center, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.
Tatsuo IchinoheDepartment of Hematology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Yoshiko HashiiDepartment of Pediatrics, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 540-0008, Japan.
Hideki GotoDivision of Laboratory and Transfusion Medicine, Hokkaido University Hospital, North-14, West-5, Kita-ku, Sapporo-shi, Hokkaido, 060-8648, Japan.
Koji KatoDepartment of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Koji KawamuraDivision of Hematology and Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori, 680-855, Japan.
Makoto OnizukaDepartment of Hematology/Oncology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
Fumihiko IshimaruJapanese Red Cross Kanto-Koshinetsu Block Blood Center, 1837 Aiko, Atsugi, Kanagawa, 243-0035, Japan.
Yoshiyuki TakahashiDepartment of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
Atsumi YanagisawaJapanese Data Center for Hematopoietic Cell Transplantation, 1-1 Yazako Karimata, Nagakute, Aichi, 480-1195, Japan.
Marie OhbikiDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
Ken TabuchiJapanese Data Center for Hematopoietic Cell Transplantation, 1-1 Yazako Karimata, Nagakute, Aichi, 480-1195, Japan.
Yoshiko AtsutaDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
Takahiro FukudaDepartment of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Junya KandaDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Makoto MurataDepartment of Hematology, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga, 520-2192, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prophylactic, diagnostic, and treatment strategies for acute graft-versus-host disease (aGVHD) may vary across medical centers and physicians. We aimed to investigate the relationship between center volume and the incidence and outcomes of aGVHD. This retrospective study included 28,786 patients who underwent their first hematopoietic stem cell transplantation (HSCT) (entire cohort) and 9498 patients who developed grade II-IV aGVHD (aGVHD cohort). Data were categorized into quartiles (very low, low, high, and very high) based on the number of HSCTs the treating center performed during the study period. We assessed the incidence of aGVHD using the entire cohort and overall survival (OS) using the aGVHD cohort. Higher center volume was associated with a higher incidence of grade II-IV aGVHD than very low center volume, with an adjusted hazard ratio of 1.07-1.11. Conversely, center volume was not associated with the incidence of grade III-IV aGVHD. OS after development of aGVHD was better in the higher center volume group than the very low-volume group, with an adjusted hazard ratio of 0.81-0.89. A very low-volume center was associated with a lower incidence of grade II-IV aGVHD in patients with allogeneic HSCT and poor survival in patients with aGVHD.

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationAcute DiseaseAdolescentAdultAgedFemaleHumansIncidenceMaleMiddle AgedRetrospective StudiesTransplantation, HomologousYoung AdultAcute graft versus host diseaseAllogeneic hematopoietic stem cell transplantationAnd Non-relapse mortalityCenter volumeOverall survival

Identifiers

PMID40392463

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.