ArticlePediatric surgery international2025
Ozonides extravirgin olive oil as an alternative to steroids in controlling proliferative behavior in penile lichen sclerosus: a comparative study in pediatric population.
Article in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Integrated Epithelial Models Reveal Anti-Inflammatory and Barrier Modulatory Properties of Ozoile in Inflammatory Bowel Disease.Antioxidants (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLichen sclerosus (LS) is a chronic inflammatory skin condition affecting genital areas and associated with autoimmune processes. Circumcision is the primary treatment for phimosis in pediatric LS, and corticosteroids are considered the best choice for medical management. Recently, Ozoile, stable ozonides obtained through green technology from extravirgin olive oil (+ OIL®), according to a patented process, has emerged as a potential alternative with fewer long-term side effects compared to corticosteroids. The aim of the study was to compare the immune and anti-proliferative effects of the pre-operative topical use of Ozoile and corticosteroids in children with phimosis associated with LS undergoing circumcision.
methodsThirty-six male patients aged 3-9 years with phimosis linked to LS were divided into three groups: Group A (no pre-operative treatment), Group B (0.1% mometasone furoate), Group C (Ozoile). Post-circumcision foreskin samples were analyzed for immune cell infiltration (CD8 +, CD57 +) and proliferation markers (Ki67,p53). Non-parametric ANOVA (Kruskal-Wallis test) and Dunn tests were used and p value less than 0.05 was considered statistically significant.
resultsHistological analysis showed acanthotic epidermis and lymphoid infiltrate in Group A, with reduced lymphocytes and markers in Groups B and C. Groups B and C showed no significant differences in CD8 + and CD57 + lymphocytes (p = 0.34, p = 0.54, respectively), but Group C had significantly lower proliferation markers Ki-67 (p = 0.035) and p53 (p = 0.039).
conclusionBoth Ozoile and corticosteroids reduced inflammatory and proliferative activity in pediatric LS patients. Ozoile showed superior suppression of proliferative markers, suggesting potential benefits for patients at risk of steroid-related side effects. Further research is needed to confirm long-term benefits.
Indexed as
Identifiers
40392382What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.