Evidence map›Paper›PMID 40392306›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2025

The SOX gene superfamily in oncogenesis: unraveling links to ncRNAs, key pathways, chemoresistance, and gene editing approaches.

Ammar Yasir Ahmed, Subasini Uthirapathy, Enwa Felix Oghenemaro, Rekha M M, Rohit Kumawat, Yasser Fakri Mustafa, Muthena Kariem, Abed J Kadhim, Shilpa Sharma, M Ravi Kumar

Abstract readReview
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In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ammar Yasir AhmedCollege of Pharmacy, University of Al Maarif, Al Anbar, 31001, Iraq.
Subasini UthirapathyPharmacy Department, Tishk International University, Erbil, Kurdistan Region, Iraq. subasini.uthirapathy@tiu.edu.iq.ORCID http://orcid.org/0000-0003-1250-388X
Enwa Felix OghenemaroDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, Delta State University, PMB 1, Abraka, Delta State, Nigeria.
Rekha M MDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
Rohit KumawatDepartment of Neurology, National Institute of Medical Sciences, NIMS University Rajasthan, Jaipur, India.
Yasser Fakri MustafaDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq.
Muthena KariemDepartment of Medical Analysis, Medical Laboratory Technique College, the Islamic University, Najaf, Iraq.
Abed J KadhimDepartment of Medical Engineering, Al-Nisour University College, Baghdad, Iraq.
Shilpa SharmaChandigarh Pharmacy College, Chandigarh Group of Colleges-Jhanjeri, Mohali, Punjab, 140307, India.
M Ravi KumarDepartment of Basic Science & Humanities, Raghu Engineering College, Visakhapatnam, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While drug resistance remains the leading cause of treatment failure, chemotherapy continues to be a crucial aspect of cancer therapy. Long noncoding RNAs (lncRNAs) regulate gene expression through various methods, including transcriptional, translational, chromatin remodeling, and epigenetic mechanisms. The SRY-related high mobility group box (HMGB) family contains 20 transcription factors with a well-recognized HMG domain, and an inappropriate regulation of SOX family members is associated with many of the phenotypes of cancer, such as tumor invasion, metastasis, proliferation, apoptosis, epithelial-mesenchymal transition, stemness, and drug resistance. This association arises because SOX family members can regulate cell fate decisions. While many articles have reported on the functionalities and activities of the SOX family, it is not clear their involvement in the tumor immune microenvironment (TIME) and the seeming contrast they can have on tumors. This study elucidates the relationship between the SOX family and ncRNAs, specifically emphasizing lncRNAs. This review article highlights the potential roles of the SOX family in cancer. It presents new therapeutic options for treating cancer, outlining the physiological roles of the SOX family and the various roles they have in tumors.

Indexed as

CarcinogenesisDrug Resistance, NeoplasmNeoplasmsRNA, Long NoncodingSOX Transcription FactorsAnimalsAntineoplastic AgentsGene EditingGene Expression Regulation, NeoplasticHumansAntineoplastic AgentsRNA, Long NoncodingSOX Transcription FactorsCancer, SOXChemoresistanceLncRNASignalling

Identifiers

PMID40392306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.