Observational studyJournal of nephrology2025
A retrospective study of kidney disease in Alport syndrome during and after pregnancy.
Observational study in Journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDuring pregnancy, hyperfiltration and other factors are hypothesized to contribute to the progression of kidney disease in women with Alport syndrome. To evaluate the status of kidney disease, clinical data from mothers with Alport syndrome in China and Europe over the pregnancy were analyzed.
methodsThis retrospective observational study collected data to evaluate proteinuria, kidney function and Alport stage prior to, during, and after pregnancy, respectively.
resultsA total of 74 women were enrolled, 82% of them with X-linked Alport syndrome and 11% with autosomal Alport syndrome (unknown in 5 patients). Detailed information on the course of pregnancy was available for 62 pregnancies from 52 different women. No fetal malformations were observed. Mean gestational age was 37.9 ± 2.7 weeks (n = 55). Complications included high blood pressure (n = 8), abortion (n = 5), preeclampsia (n = 5), gestational diabetes (n = 3), nephrotic syndrome (n = 2), cervical insufficiency with fetal growth delay (n = 2), premature rupture of membranes (n = 1) and acute intrauterine fetal distress (n = 1). Median proteinuria was 350 (30-2465) mg/day prior to pregnancy, 2390 (450-11,450) mg/day during pregnancy, and 590 (40-2650) mg/day at a mean postpartum follow-up time of 4.5 ± 2.1 years. Mean estimated glomerular filtration rate (eGFR) decreased by 17.2 ± 16.7 ml/min/1.73 m
conclusionsThis study provides important data on the natural history of Alport syndrome in women who have undergone a pregnancy. Women with severe variants of Alport syndrome, and women with eGFR below 90 ml/min/1.73 m
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