ReviewJournal of materials science. Materials in medicine2025
An update on the effect of metals on stemness properties of mesenchymal stem cells.
Review in Journal of materials science. Materials in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A Systematic Review of Metal Composite Bone Grafts in Preclinical Spinal Fusion Models.Biomimetics (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metal-based devices may corrode, degrade, or release metal ions and fragments after being implanted in the body, exhibiting their own consequences on hosting organs/tissues. The biocompatibility of metal implants has been investigated in various studies using a number of cell types. Mesenchymal stem cells (MSCs) are more relevant cells than others for evaluating the cytocompatibility of metal-based orthopedic implants because they are essential cells for bone regeneration and a promising cell population in regenerative medicine. In this regard, stemness preservation of MSCs is a key property in both body's own repair process and success of renewing/compensating approaches. In general, MSCs adhesion, viability, and function at the cell-metal interface is directly dependent on the metal alloys composing elements, which, along with consideration of compatibility, could guarantee the success of implants. This review scrutinizes the effects of orthopedic metal materials on the biocompatibility and stemness of MSCs at metal interface. Additionally, in vivo, host responses to metal implants are investigated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.