Evidence map›Paper›PMID 40392238›Full record

ArticleeLife2025

Flower/FLWR-1 regulates neuronal activity via the plasma membrane Ca

Marius Seidenthal, Jasmina Redzovic, Jana F Liewald, Dennis Rentsch, Stepan Shapiguzov, Noah Schuh, Nils Rosenkranz, Stefan Eimer, Alexander Gottschalk

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Basal cytoplasmic calcium levels regulatebioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marius SeidenthalBuchmann Institute for Molecular Life Sciences, Goethe-University, Frankfurt, Germany.ORCID https://orcid.org/0009-0001-0563-7719
Jasmina Redzovic *Buchmann Institute for Molecular Life Sciences, Goethe-University, Frankfurt, Germany.
Jana F Liewald *Buchmann Institute for Molecular Life Sciences, Goethe-University, Frankfurt, Germany.ORCID https://orcid.org/0000-0002-2050-0745
Dennis RentschBuchmann Institute for Molecular Life Sciences, Goethe-University, Frankfurt, Germany.ORCID https://orcid.org/0009-0006-9090-9016
Stepan ShapiguzovBuchmann Institute for Molecular Life Sciences, Goethe-University, Frankfurt, Germany.
Noah SchuhBuchmann Institute for Molecular Life Sciences, Goethe-University, Frankfurt, Germany.ORCID https://orcid.org/0009-0000-1888-7998
Nils RosenkranzBuchmann Institute for Molecular Life Sciences, Goethe-University, Frankfurt, Germany.
Stefan EimerInstitute of Cell Biology and Neuroscience, Goethe-University, Frankfurt, Germany.
Alexander GottschalkBuchmann Institute for Molecular Life Sciences, Goethe-University, Frankfurt, Germany.ORCID https://orcid.org/0000-0002-1197-6119

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Deutsche Forschungsgemeinschaft CRC1080/B2Deutsche Forschungsgemeinschaft GO1011/13-2NIH HHS P40 OD010440
6 · The paper itself

Abstract

The Flower protein was suggested to couple the fusion of synaptic vesicles (SVs) to their recycling in different model organisms. It is supposed to trigger activity-dependent bulk endocytosis by conducting Ca

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsNeuronsPlasma Membrane Calcium-Transporting ATPasesSynaptic VesiclesAnimalsCalciumCell MembraneEndocytosisNeuromuscular JunctionSynaptic TransmissionCaenorhabditis elegans ProteinsCalciumPlasma Membrane Calcium-Transporting ATPasesCa2+ homeostasisC. elegansendocytosisneurosciencePIP2plasma membran Ca2+ ATPasesynaptic vesicle recycling

Identifiers

PMID40392238
PMCPMC12092002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.