Evidence map›Paper›PMID 40392222›Full record

ArticleeLife2025

Secretory leukocyte protease inhibitor influences periarticular joint inflammation in

Qian Yu, Xiaotian Tang, Thomas Hart, Robert Homer, Alexia A Belperron, Linda K Bockenstedt, Aaron Ring, Akira Nakamura, Erol Fikrig

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Qian Yu *Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.ORCID https://orcid.org/0000-0002-2396-2128
Xiaotian Tang *Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.ORCID https://orcid.org/0000-0002-0171-9354
Thomas HartSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.
Robert HomerDepartment of Pathology, Yale School of Medicine, New Haven, United States.ORCID https://orcid.org/0000-0002-2055-5885
Alexia A BelperronSection of Rheumatology, Allergy and Immunology, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.
Linda K BockenstedtSection of Rheumatology, Allergy and Immunology, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.ORCID https://orcid.org/0000-0001-9349-8757
Aaron RingDepartment of Immunobiology, Yale School of Medicine, New Haven, United States.
Akira NakamuraDivisions of Immunology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Erol FikrigSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.

Funding

Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI WAJAHAT Zafar MEHAL · 1986 to 2026
$31.1M
Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Erol Fikrig, UTPAL PAL · 2018 to 2026
$13.5M
A novel Lyme disease vaccineR01AI165499 · NIAID · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR, FIKRIG, EROL · 2022 to 2025
$3.2M
Howard Hughes Medical Institute Emerging Pathogens InitiativeNational Institute of Allergy and Infectious Diseases AI138949National Institute of Allergy and Infectious Diseases AI165499NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI165499NIDDK NIH HHS P30 DK034989
6 · The paper itself

Abstract

Lyme disease, caused by

Indexed as

Borrelia burgdorferiInflammationLyme DiseaseSecretory Leukocyte Peptidase InhibitorAnimalsDisease Models, AnimalFemaleMacrophagesMiceMice, Inbred C57BLMice, KnockoutNeutrophilsSecretory Leukocyte Peptidase InhibitorSlpi protein, mouseanti-proteaseB. burgdorferiinfectious diseaseinflammationLyme arthritismicrobiologySLPI

Identifiers

PMID40392222
PMCPMC12092001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.