Evidence map›Paper›PMID 40392169›Full record

ArticleJACC. Advances2025

Improving Cardiovascular Clinical Competencies for the Menopausal Transition: A Focus on Cardiometabolic Health in Midlife.

Lily N Dastmalchi, Martha Gulati, Rebecca C Thurston, Emily Lau, Amy Sarma, Cherie Q Marfori, Allison E Gaffey, Stephanie Faubion, Deepika Laddu, Chrisandra L Shufelt and 1 more

Abstract read
In one paragraph

Article in JACC. Advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Preventive Cardiovascular Medication Prescribing Patterns in Menopausal Women.Mayo Clinic proceedings. Innovations, quality & outcomes · 2026
    Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lily N DastmalchiInova Schar Heart and Vascular, Department of Cardiology, Inova Health Systems, Fairfax, Virginia, USA. Electronic address: lily.dastmalchi@inova.org.
Martha GulatiBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Rebecca C ThurstonDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA.
Emily LauDivision of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Amy SarmaHeart Vascular Institute, Mass General Brigham, Boston, Massachusetts, USA.
Cherie Q MarforiDepartment of Obstetrics & Gynecology, Inova Health System, Fairfax, Virginia, USA.
Allison E GaffeyDepartment of Internal Medicine (Section of Cardiovascular Medicine), Yale School of Medicine, West Haven, Connecticut, USA; VA Connecticut Healthcare System, West Haven, Connecticut, USA.
Stephanie FaubionDivision of General Internal Medicine, Mayo Clinic, Jacksonville, Florida, USA; Mayo Clinic Center for Women's Health, Boston, Massachusetts, USA.
Deepika LadduDepartment of Preventive Medicine, Northwestern University, Chicago, Illinois, USA.
Chrisandra L ShufeltDivision of General Internal Medicine, Mayo Clinic, Jacksonville, Florida, USA; Mayo Clinic Center for Women's Health, Boston, Massachusetts, USA.
Garima SharmaInova Schar Heart and Vascular, Department of Cardiology, Inova Health Systems, Fairfax, Virginia, USA.

Funding

ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2M
The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old AgeU19AG063720 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Arun S Karlamangla · 2020 to 2026
$61.3M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
CARDIOVASCULAR BEHAVIORAL MEDICINE RESEARCH TRAININGT32HL007560 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peter J Gianaros, REBECCA C THURSTON · 1985 to 2026
$11.3M
Women's Ischemia Syndrome EvaluationU01HL064829 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KELSEY, SHERYL F. · 2001 to 2005
$3.9M
Menopausal Vasomotor Symptoms and Brain Aging in WomenR01AG053504 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MAKI, PAULINE M, THURSTON, REBECCA C · 2021 to 2025
$3.8M
Women's Ischemia Syndrome Evaluation (WISE) - Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure with Preserved Ejection Fraction (HFpEF)R01HL146158 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL · 2019 to 2023
$3.7M
Hypothalamic Amenorrhea as a Fertility Status Marker for Cardiovascular HealthR01HD106096 · NICHD · MAYO CLINIC JACKSONVILLE · PI SHUFELT, CHRISANDRA LEE · 2021 to 2024
$3.6M
Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular DysfunctionR01HL090957 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL, PEPINE, CARL J · 2008 to 2013
$3.5M
Whole-Heart Myocardial Blood Flow Quantification Using MRIR01HL124649 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI LI, DEBIAO · 2015 to 2018
$3.3M
Myocardial Steatosis in Women with Coronary Microvascular Dysfunction: Defining the Pathway to Heart Failure with Preserved Ejection Fraction (HFpEF)R01HL153500 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI WEI, JANET · 2021 to 2025
$3.2M
MenoBrain: A Longitudinal Investigation of Menopause and Brain HealthR01AG090417 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PAULINE M MAKI, REBECCA C THURSTON · 2025 to 2026
$3.1M
NCATS NIH HHS UL1 TR000124NCRR NIH HHS M01 RR000425NHLBI NIH HHS K23 HL105787NHLBI NIH HHS K23 HL125941NHLBI NIH HHS K23 HL127262NHLBI NIH HHS K23 HL151867NHLBI NIH HHS K23 HL159243NHLBI NIH HHS K23 HL168233NHLBI NIH HHS K24 HL123565NHLBI NIH HHS N01 HV068161NHLBI NIH HHS N01 HV068162NHLBI NIH HHS N01 HV068163NHLBI NIH HHS N01 HV068164NHLBI NIH HHS R01 HL090957NHLBI NIH HHS R01 HL124649NHLBI NIH HHS R01 HL146158NHLBI NIH HHS R01 HL153500NHLBI NIH HHS T32 HL007560NHLBI NIH HHS T32 HL069751NHLBI NIH HHS U01 HL064829NIA NIH HHS R01 AG053504NIA NIH HHS R01 AG090417NIA NIH HHS R03 AG032631NIA NIH HHS U19 AG063720NICHD NIH HHS R01 HD106096
6 · The paper itself

Abstract

Cardiovascular disease (CVD) is the leading cause of death in women with an increase in risk after menopause. Over the past 20 years, longitudinal studies have helped differentiate the influence of chronological aging from ovarian aging on cardiovascular health. In addition to the pronounced sex hormone changes of the menopause transition (MT), the MT is also often accompanied by vasomotor symptoms, sleep problems, and mental health changes that impact women's cardiovascular health. The purpose of this invited review is to highlight the key changes that can alter CVD risk. Given the gaps in medical training, we also describe the need for specialized postgraduate curriculum in managing the MT with an aim to improve MT screening and management of CVD during this universal life stage. Finally, we propose a multidisciplinary approach led by experts in women's cardiovascular health and present an approach utilizing validated screening tools and CVD risk scores to discuss the candidacy of systemic menopause hormone therapy.

Indexed as

cardiometabolic syndromecardiovascular diseasehormone therapymenopausemenopause transition

Identifiers

PMID40392169
PMCPMC12277619

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.