Evidence map›Paper›PMID 40392123›Full record

ArticleEpilepsia2025

Comparison of children and adults undergoing subdural grid electrode implantation or stereoelectroencephalography in a refractory epilepsy cohort from four European centers.

Matea Rados, Shanice Beerepoot, Martin M Tisdall, Ronit M Pressler, J Helen Cross, Rachel C Thornton, Beate Diehl, Andrew W McEvoy, Anna Miserocchi, Josemir W Sander and 12 more

Abstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Matea RadosDepartment of Child Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht (member of European Reference Network for Rare and Complex Epilepsies EpiCARE), Utrecht University, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0003-3745-2740
Shanice BeerepootDepartment of Child Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht (member of European Reference Network for Rare and Complex Epilepsies EpiCARE), Utrecht University, Utrecht, the Netherlands.
Martin M TisdallDepartment of Neurology, Neurophysiology, and Neurosurgery, Institute of Child Health, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.ORCID https://orcid.org/0000-0001-8880-8386
Ronit M PresslerDepartment of Neurology, Neurophysiology, and Neurosurgery, Institute of Child Health, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.ORCID https://orcid.org/0000-0002-2905-6839
J Helen CrossDepartment of Neurology, Neurophysiology, and Neurosurgery, Institute of Child Health, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.ORCID https://orcid.org/0000-0001-7345-4829
Rachel C ThorntonDepartment of Neurology, Neurophysiology, and Neurosurgery, Institute of Child Health, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.
Beate DiehlUCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom.ORCID https://orcid.org/0000-0002-6896-854X
Andrew W McEvoyUCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom.
Anna MiserocchiUCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom.
Josemir W SanderUCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom.ORCID https://orcid.org/0000-0001-6041-9661
John S DuncanUCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom.
Jane de TisiDepartment of Clinical and Experimental Epilepsy, University College London Queen Square Institute of Neurology and National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, London, United Kingdom.
Francesco CardinaleDepartment of Neurosciences, Niguarda Hospital, "Claudio Munari" Epilepsy Surgery Center (member of European Reference Network for Rare and Complex Epilepsies EpiCARE), Milan, Italy.ORCID https://orcid.org/0000-0002-5141-9202
Laura TassiDepartment of Neurosciences, Niguarda Hospital, "Claudio Munari" Epilepsy Surgery Center (member of European Reference Network for Rare and Complex Epilepsies EpiCARE), Milan, Italy.
Giorgio Lo RussoDepartment of Neurosciences, Niguarda Hospital, "Claudio Munari" Epilepsy Surgery Center (member of European Reference Network for Rare and Complex Epilepsies EpiCARE), Milan, Italy.
Stefano FrancioneDepartment of Neurosciences, Niguarda Hospital, "Claudio Munari" Epilepsy Surgery Center (member of European Reference Network for Rare and Complex Epilepsies EpiCARE), Milan, Italy.
Herm J LamberinkDepartment of Child Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht (member of European Reference Network for Rare and Complex Epilepsies EpiCARE), Utrecht University, Utrecht, the Netherlands.
Frans S S LeijtenDepartment of Child Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht (member of European Reference Network for Rare and Complex Epilepsies EpiCARE), Utrecht University, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0003-2603-3364
Willem M OtteDepartment of Child Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht (member of European Reference Network for Rare and Complex Epilepsies EpiCARE), Utrecht University, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0003-1511-6834
Sandra M A van der SalmDepartment of Child Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht (member of European Reference Network for Rare and Complex Epilepsies EpiCARE), Utrecht University, Utrecht, the Netherlands.
Kees P J BraunDepartment of Child Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht (member of European Reference Network for Rare and Complex Epilepsies EpiCARE), Utrecht University, Utrecht, the Netherlands.
Pieter van EijsdenDepartment of Child Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht (member of European Reference Network for Rare and Complex Epilepsies EpiCARE), Utrecht University, Utrecht, the Netherlands.

Funding

Gierard de Mielet-van Coehoorn StichtingNederlandse Vereniging voor KinderneurologieWilhelmina Kinderziekenhuis
6 · The paper itself

Abstract

objectiveChildren with refractory focal epilepsy differ from adults, although many centers will offer invasive electroencephalography (iEEG) to both. Outcomes in terms of likelihood of resection and subsequent seizure outcome after either subdural grid electrode implantation (SDE) or stereoelectroencephalography (SEEG) have, however, not been directly compared between age groups.

methodsWe retrospectively included adults and children undergoing iEEG monitoring at four European centers. We compared the two age groups and techniques regarding complication rate, chance of proceeding to resection, and seizure freedom.

resultsIn total, 857 individuals were included (447 SEEG, 410 SDE; 572 adults, 285 children). Adults more often had a history of focal to bilateral tonic-clonic seizures (FBTCS) and prior epilepsy surgery and were more often magnetic resonance imaging-negative. Children had a higher seizure frequency and rate of preexisting neurologic deficits. In SEEG, likelihood of resection was 64% in adults and 76% in children (p < .05), but chance of seizure freedom did not differ. Adults and children had similar chances of resection and seizure freedom rates after SDE. In children, postoperative seizure freedom was less likely after SDE than SEEG. In adults, history of FBTCS was associated with lower chance of seizure freedom. Overall complication rate was higher in children (22% vs. adults 15%) and in SDE (29% vs. SEEG 7%). SIGNIFICANCE: Either iEEG technique provides an equally valid but very different road to success, with no difference in seizure outcome between the two age groups, but with higher risk of complications in SDE. We found similar surgical results for dissimilar techniques and a higher threshold for children. In case of an assumed lower chance of focality of epilepsy or chance of seizure freedom after resection, adults were more often explored with iEEG, whereas children were more severely affected when considered for iEEG.

Indexed as

Drug Resistant EpilepsyElectrodes, ImplantedElectroencephalographyStereotaxic TechniquesAdolescentAdultAge FactorsChildChild, PreschoolCohort StudiesEuropeFemaleHumansMaleMiddle AgedRetrospective Studiesepilepsy surgeryinvasive electroencephalographySEEG

Identifiers

PMID40392123
PMCPMC12371617

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.