Evidence map›Paper›PMID 40392085›Full record

ArticleRadiology2025

Risk of Malignancy in Cystic Lung Lesions in a Lung Cancer CT Screening Program.

Suzanne C Byrne, Andetta R Hunsaker, Mark M Hammer

Abstract read
In one paragraph

Article in Radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Suzanne C ByrneDepartment of Radiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115.ORCID 0000-0001-7059-9774
Andetta R HunsakerDepartment of Radiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115.ORCID 0000-0003-1344-9053
Mark M HammerDepartment of Radiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115.ORCID 0000-0002-1700-7984

Funding

Optimizing Lung Cancer Screening Nodule EvaluationR01CA260889 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KONG, CHUNG YIN, SIGEL, KEITH MAGNUS · 2021 to 2025
$3.5M
NCI NIH HHS R01 CA260889
6 · The paper itself

Abstract

Background There is currently a lack of consensus regarding the risk of malignancy and the natural history of cystic lung lesions. Purpose To evaluate imaging characteristics associated with the risk of malignancy of cystic lung lesions in a lung cancer screening program. Materials and Methods This retrospective study included all CT lung cancer screening examinations performed from January 2015 to July 2023 in a large health care network. Radiology reports were queried for cystic lesions. Baseline CT images were reviewed, and lesion morphologic characteristics and size were recorded. All follow-up CT scans were evaluated for changes in the lesion. The risk of growth and diagnosis of cancer over time were analyzed with Kaplan-Meier curves. Results Among 15 762 patients, 235 were found to have cystic lung lesions; 33 (14%) of these patients were diagnosed with lung cancer arising from the cystic lesion. Increased risk of cancer was associated with nodular wall thickening (odds ratio [OR], 11;

Indexed as

CystsEarly Detection of CancerLung NeoplasmsTomography, X-Ray ComputedAgedFemaleHumansLungMaleMiddle AgedRetrospective StudiesRisk Factors

Identifiers

PMID40392085
PMCPMC12127957

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.