Evidence map›Paper›PMID 40391973›Full record

ArticlemBio2025

Linear dicentric chromosomes in bacterial natural isolates reveal common constraints for replicon fusion.

Ram Sanath-Kumar, Arafat Rahman, Zhongqing Ren, Ian P Reynolds, Lauren Augusta, Clay Fuqua, Alexandra J Weisberg, Xindan Wang

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Draft genome sequence ofMicrobiology resource announcements · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ram Sanath-Kumar *Department of Biology, Indiana University, Bloomington, Indiana, USA.ORCID 0009-0004-5793-2498
Arafat Rahman *Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon, USA.ORCID 0000-0003-4222-9615
Zhongqing RenDepartment of Biology, Indiana University, Bloomington, Indiana, USA.ORCID 0000-0003-1788-5362
Ian P ReynoldsDepartment of Biology, Indiana University, Bloomington, Indiana, USA.
Lauren AugustaDepartment of Biology, Indiana University, Bloomington, Indiana, USA.
Clay FuquaDepartment of Biology, Indiana University, Bloomington, Indiana, USA.ORCID 0000-0001-7051-1760
Alexandra J WeisbergDepartment of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon, USA.ORCID 0000-0002-0045-1368
Xindan WangDepartment of Biology, Indiana University, Bloomington, Indiana, USA.ORCID 0000-0001-6458-180X

Funding

Physicochemical properties driving membraneless organelle assembly in bacteriaR01GM143182 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BITEEN, JULIE, MEYER, ANNE SARA · 2021 to 2024
$2.4M
Graduate Training Program in Quantitative and Chemical Biology at Indiana University BloomingtonT32GM131994 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI JARED C LEWIS · 2019 to 2026
$2.4M
Determining the molecular basis of gene silencing by MucR and defining its role in Brucella virulenceR01AI172822 · NIAID · EAST CAROLINA UNIVERSITY · PI ROY M ROOP · 2023 to 2026
$2.3M
How bacterial SMC complexes organize chromosomes (Equipment Supplement)R01GM141242 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI WANG, XINDAN · 2021 to 2025
$1.8M
National Institute of Allergy and Infectious Diseases R01AI172822National Science Foundation 2022049NIAID NIH HHS R01 AI172822NIGMS NIH HHS R01 GM141242NIGMS NIH HHS R01GM141242, R01GM143182NIGMS NIH HHS R01 GM143182NIGMS NIH HHS T32 GM131994
6 · The paper itself

Abstract

Multipartite bacterial genome organization can confer advantages, including coordinated gene regulation and faster genome replication, but is challenging to maintain. IMPORTANCE: Most bacterial genomes are monopartite with a single, circular chromosome. However, some species, like

Indexed as

Agrobacterium tumefaciensChromosomes, BacterialRepliconDNA ReplicationGenome, BacterialPlasmidsReplication OriginAgrobacterium tumefacienschromosome fusionHi-Cmultipartite genomenatural isolates

Identifiers

PMID40391973
PMCPMC12153318

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.