Evidence map›Paper›PMID 40391941›Full record

ArticleAntimicrobial agents and chemotherapy2025

Classic and new candidate markers for drug resistance in a large cohort of leprosy patients from the Amazon state, Brazil.

Cynthia de Oliveira Ferrreira, André Luiz Leturiondo, Camila Gurgel Dos Santos, Jaqueline Bentes da Silva, Michelle Fernanda de Andrade Souza, Catherine Bianca Oliveira Rego, Guilherme Caldas de Souza, Thamires Bastos Pinheiro, Gisely Cardoso Melo, Patricia Sammarco Rosa and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cynthia de Oliveira FerrreiraLaboratório de Biologia Molecular, Fundação Hospitalar Alfredo da Matta-FUHAM, Manaus, Amazonas, Brazil.ORCID 0000-0003-3069-2434
André Luiz LeturiondoLaboratório de Biologia Molecular, Fundação Hospitalar Alfredo da Matta-FUHAM, Manaus, Amazonas, Brazil.
Camila Gurgel Dos SantosLaboratório de Biologia Molecular, Fundação Hospitalar Alfredo da Matta-FUHAM, Manaus, Amazonas, Brazil.
Jaqueline Bentes da SilvaLaboratório de Biologia Molecular, Fundação Hospitalar Alfredo da Matta-FUHAM, Manaus, Amazonas, Brazil.
Michelle Fernanda de Andrade SouzaLaboratório de Biologia Molecular, Fundação Hospitalar Alfredo da Matta-FUHAM, Manaus, Amazonas, Brazil.
Catherine Bianca Oliveira RegoLaboratório de Biologia Molecular, Fundação Hospitalar Alfredo da Matta-FUHAM, Manaus, Amazonas, Brazil.
Guilherme Caldas de SouzaLaboratório de Biologia Molecular, Fundação Hospitalar Alfredo da Matta-FUHAM, Manaus, Amazonas, Brazil.
Thamires Bastos PinheiroLaboratório de Biologia Molecular, Fundação Hospitalar Alfredo da Matta-FUHAM, Manaus, Amazonas, Brazil.
Gisely Cardoso MeloPrograma de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas-UEA, Manaus, Amazonas, Brazil.ORCID 0000-0002-8155-6005
Patricia Sammarco RosaLaboratório de Biologia Molecular, Instituto Lauro de Souza Lima, Bauru, Brazil.
Marcelo Távora MiraGraduate Program in Health Sciences, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Charlotte AvanziMycobacteria Research Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Carolina TalhariLaboratório de Biologia Molecular, Fundação Hospitalar Alfredo da Matta-FUHAM, Manaus, Amazonas, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug therapy for leprosy is highly effective and the recommended standard of care for leprosy worldwide. However, reports of antimicrobial resistance (AMR) have emerged globally. This study aimed to estimate the frequency of primary and secondary AMR associated with leprosy in patients treated at the Alfredo da Matta Foundation, Manaus, Amazonas, Brazil, as well as to determine the circulating subtypes of

Indexed as

Drug Resistance, BacterialDrug Resistance, Multiple, BacterialLeprostatic AgentsLeprosyMycobacterium lepraeAdolescentAdultBacterial ProteinsBrazilCohort StudiesDNA GyraseFemaleHumansMaleMicrobial Sensitivity TestsMiddle AgedBacterial ProteinsDNA GyraseLeprostatic Agentsantimicrobial resistanceBrazilian Amazon regionDNA sequence analysisleprosy

Identifiers

PMID40391941
PMCPMC12217464

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.