Evidence map›Paper›PMID 40391923›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2025

Drug Resistance in People With Viremia on Dolutegravir-based Antiretroviral Therapy in Sub-Saharan Africa: The DTG RESIST Study.

Tom Loosli, Carolyn Bolton Moore, Lydia Buzaalirwa, Helen Byakwaga, İpek Çelikağ, Cleophas Chimbetete, Peter Vanes Ebasone, Jennifer Giandhari, Nuri Han, Jacqueline Huwa and 13 more

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Tom LoosliDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0003-2049-3562
Carolyn Bolton MooreCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.ORCID 0000-0001-9103-7746
Lydia BuzaalirwaAIDS Healthcare Foundation Uganda Cares, Masaka, Uganda.
Helen ByakwagaFaculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.ORCID 0000-0002-4799-1564
İpek ÇelikağInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.ORCID 0000-0002-2172-6463
Cleophas ChimbeteteNewlands Clinic, Harare, Zimbabwe.ORCID 0000-0002-3756-3523
Peter Vanes EbasoneHôpital Jamot, Yaoundé and Regional Hospital, Limbé, Cameroon.
Jennifer GiandhariKwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa.
Nuri HanDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Jacqueline HuwaLighthouse Trust, Lilongwe, Malawi.ORCID 0000-0001-8786-2487
Charles KasoziPublic Health Department, Regional Referral Hospital, Masaka, Uganda.
Adolphe MafouaCentre de Traitement Ambulatoire, Pointe Noire, Republic of the Congo.
Eugène MessouCentre de Prise en Charge, de Recherche et de Formation, Abidjan, Côte d'Ivoire.
Albert MingaCentre National de Transfusion Sanguine, Abidjan, Côte d'Ivoire.ORCID 0000-0003-2357-6902
Guy MuulaCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Winnie MuyindikeFaculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.ORCID 0000-0002-6694-2645
Arcel Christ Massamba NdalaCentre de Traitement Ambulatoire, Brazzaville, Republic of the Congo.
Mamatha SauermannInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Aggrey SemeereInfectious Diseases Institute, Makerere University, Kampala, Uganda.ORCID 0000-0003-1826-2239
Lavanya SinghKwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa.
Roger D KouyosDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0002-9220-8348
Richard LessellsKwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa.ORCID 0000-0003-0926-710X
Matthias EggerInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.ORCID 0000-0001-7462-5132

Funding

Malawi HIV Implementation Research Scientist Training Program (MHIRST)D43TW010060 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MINA CHRISTINE HOSSEINIPOUR, Victor Mwapasa · 2015 to 2026
$3.8M
HIV-1 subtype-specific drug resistance in patients failing Dolutegravir-based 1st, 2nd or 3rd line regimens: the International epidemiological Databases to Evaluate AIDS (IeDEA)R01AI152772 · NIAID · UNIVERSITY OF ZURICH · PI Roger Dimitri Kouyos · 2021 to 2026
$3.2M
FIC NIH HHS D43 TW010060NIAID NIH HHS R01 AI152772Swiss National Science Foundation 324730_207957Swiss National Science Foundation 32FP30_207285
6 · The paper itself

Abstract

Dolutegravir resistance is an increasing concern. An analysis of the DTG RESIST study found that among 227 integrase sequences from 7 African countries (all non-B subtypes), 59 (26.0%) had at least 1 major drug resistance mutation (primarily G118R and E138A/K/T), with 49 (21.6%) predicted to have high-level resistance to dolutegravir.

Indexed as

Drug Resistance, ViralHeterocyclic Compounds, 3-RingHIV-1HIV InfectionsHIV Integrase InhibitorsViremiaAfrica South of the SaharaDolutegravirHIV IntegraseHumansMaleMutationOxazinesPiperazinesPyridonesDolutegravirHeterocyclic Compounds, 3-RingHIV IntegraseHIV Integrase InhibitorsOxazinesPiperazinesPyridonesdolutegravirdrug resistanceHIVsub-Saharan Africaviremia

Identifiers

PMID40391923
PMCPMC12596406

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.