ArticleMicrobiology spectrum2025
Esophageal cancer and precancerous lesions: focus on resident bacteria and fungi.
Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Early esophageal squamous neoplasia and the microbiome: evidence, mechanisms, and early-detection potential.Frontiers in microbiology · 2026Review
- Profiling of the mycobiome and metabolome: a comparative study of benign pulmonary nodules and lung adenocarcinoma.Frontiers in cellular and infection microbiology · 2026Article
- Single-Cell RNA-Seq Reveals the Effect of Commensal Bacteria on the Multistep Development of Esophageal Cancer.Cancer science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Accumulating evidence highlights the pivotal role of microbiomes in cancer development. To elucidate the esophageal microbiome's characteristics during esophageal squamous cell carcinoma (ESCC) progression, normal tissues from 13 healthy controls (HC), paired esophageal squamous intraepithelial neoplasia (ESIN) lesional and adjacent (ESINA) tissues from 10 ESIN individuals, and ESCC lesional and adjacent (ESCCA) tissues from 12 ESCC individuals were collected. Following 16S rRNA and ITS sequencing, analyses encompassed α/β-diversity assessments, shared species identification, Type-I Taylor's Power Law Extensions (TPLE), linear discriminant analysis effect size (LEfSe), co-occurrence networks, receiver operating characteristic (ROC) curve analysis, and functional predictions. Distinct microbial signatures characterized HC, precancerous, and cancerous groups. The ESIN group exhibited unique microbial features, including diminished bacterial and fungal species sharing relative to the ESINA group and maximal IMPORTANCE: This study collected esophageal tissues through gastroscopic biopsy and conducted sequencing and analyses to explore the diversity, heterogeneity, key microbial composition, interaction networks, and functional predictions of resident bacteria and fungi in esophageal squamous cell carcinoma (ESCC) progression. The esophageal squamous intraepithelial neoplasia group showed the highest heterogeneity in oral microbiome and fungi, with certain species potentially contributing to ESCC progression. Targeting the oral microbiome in high-risk populations may thus provide a valuable approach for improving early diagnosis and potentially intervening in disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.