Evidence map›Paper›PMID 40391770›Full record

ArticleJournal of the peripheral nervous system : JPNS2025

Feasibility, Validity, and Reliability of the Virtual CMT Infant Toddler Scale (vCMTInfS): A Remote Evaluation of Infants/Toddlers With CMT.

Rosemary Shy, Amanda Dragon, Shawna M E Feely, Gabrielle Donlevy, Kayla Cornett, Melissa Mandarakas, Tim Estilow, Joshua Burns, Michael E Shy

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the peripheral nervous system : JPNS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rosemary ShyDepartment of Neurology, Neuromuscular and Neurogenetics Division, University of Iowa Health Care, Carver College of Medicine, Iowa City, Iowa, USA.
Amanda DragonDepartment of Neurology, Neuromuscular and Neurogenetics Division, University of Iowa Health Care, Carver College of Medicine, Iowa City, Iowa, USA.
Shawna M E FeelyDivision of Pediatric Neurology, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, USA.
Gabrielle DonlevyFaculty of Medicine and Health, University of Sydney School of Health Sciences, The Children's Hospital Westmead, Westmead, Australia.
Kayla CornettSydney Children's Hospitals Network and Discipline of Paediatrics and Child Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Melissa MandarakasSydney Children's Hospitals Network and Discipline of Paediatrics and Child Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Tim EstilowDepartment of Occupational Therapy, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Joshua BurnsDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Michael E ShyDepartment of Neurology, Neuromuscular and Neurogenetics Division, University of Iowa Health Care, Carver College of Medicine, Iowa City, Iowa, USA.ORCID https://orcid.org/0000-0001-8460-6971

Funding

trainingU54NS065712 · NINDS · WAYNE STATE UNIVERSITY · PI SHY, MICHAEL E. · 2009 to 2023
$19.6M
Charcot-Marie-Tooth AssociationMuscular Dystrophy AssociationNINDS NIH HHS U54 NS065712
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe CMT Infant Scale (CMTInfS) enables evaluation of infants/toddlers in clinic. Our aim was to evaluate the feasibility, reliability, and validity of a virtual version of the CMTInfS (vCMTInfS).

methodsChildren aged 55 months or less were evaluated either in clinic using CMTInfS or remotely via telemedicine using the vCMTInfS. A trained clinical evaluator remotely directed activities with assistance from the parent/caregiver. vCMTInfS scores were calculated using the CMTInfS calculator available at www.ClinicalOutcomeMeasures.org. Clinical evaluators also used the Brazelton Neonatal Behavior assessment scale to give insight into the behavior of the child during the exam.

resultsTwenty children (10 males and 10 females) aged 6-55 months with confirmed or at risk for CMT were evaluated. The mean in person (IP) CMT Infant and Toddler Scale (CMTInfS) raw score (4.11, SD = 2.76) was not significantly different from the mean initial virtual (V1) CMTInfS raw score (3.78, SD = 2.59) using a two-tailed test (t = 1.000, p = 0.347). Differences between the first and second (V2) visits as well as between the IP and V2 visits were also nonsignificant.

interpretationOur data demonstrate that children aged 55 months or less can be effectively evaluated remotely using the vCMTInfS, which will expand the number of very young children who can be evaluated with rare forms of CMT.

Indexed as

Charcot-Marie-Tooth DiseaseSeverity of Illness IndexChild, PreschoolFeasibility StudiesFemaleHumansInfantMaleReproducibility of ResultsTelemedicineCMTinfantsoutcomestelemedicinetoddlers

Identifiers

PMID40391770
PMCPMC12090703

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.