ArticleDiagnostic and interventional radiology (Ankara, Turkey)2025
Amide proton transfer-weighted magnetic resonance imaging for the evaluation of testicular spermatogenic function: a preliminary study.
Article in Diagnostic and interventional radiology (Ankara, Turkey), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo determine the amide proton transfer-weighted (APTw) imaging features in testes with age, and to assess the feasibility of APTw magnetic resonance imaging (MRI) in assessing testicular spermatogenic function.
methodsA total of 23 male patients with clinically confirmed hypospermatogenesis caused by epididymo-orchitis were included in the case group (group A) and another 93 men (age range, 20-80 years) were included in the control group. The control group was divided into four subgroups: group B1 (20-34 years, n = 25), group B2 (35-49 years, n = 23), group B3 (50-64 years, n = 21), and group B4 (65-80 years, n = 24). All participants underwent 3.0T MRI scan, and the APT signal intensity (SI) and apparent diffusion coefficient (ADC) value of each testis were examined. The ADC and APT SI were independently measured by two radiologists blinded to clinical data, and average values were calculated. A power analysis was conducted to determine the required sample size.
resultsAPT SI was negatively correlated with age (r = -0.510,
conclusionThe APT SI of the normal testes decreased with age, whereas a significant elevation of APT SI was detected in patients with hypospermatogenesis caused by epididymo-orchitis. CLINICAL SIGNIFICANCE: Hypospermatogenesis caused by degeneration or inflammation can be differentiated by APT quantity combined with ADC value.
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